Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 1568683..1570364 Replicon chromosome
Accession NZ_CP097385
Organism Klebsiella pneumoniae strain KPTCM

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag M6G79_RS07425 Protein ID WP_004178299.1
Coordinates 1568683..1569600 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M6G79_RS07430 Protein ID WP_004177809.1
Coordinates 1569606..1570364 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G79_RS07405 (1563989) 1563989..1565509 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
M6G79_RS07410 (1565506) 1565506..1566504 + 999 WP_002885172.1 ribose ABC transporter permease -
M6G79_RS07415 (1566535) 1566535..1567476 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M6G79_RS07420 (1567551) 1567551..1568558 + 1008 WP_004178300.1 carbohydrate kinase family protein -
M6G79_RS07425 (1568683) 1568683..1569600 - 918 WP_004178299.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M6G79_RS07430 (1569606) 1569606..1570364 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M6G79_RS07435 (1570450) 1570450..1571178 - 729 WP_004178298.1 response regulator transcription factor -
M6G79_RS07440 (1571451) 1571451..1573598 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
M6G79_RS07445 (1573595) 1573595..1573738 - 144 WP_022631365.1 hypothetical protein -
M6G79_RS07450 (1574176) 1574176..1574862 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34649.06 Da        Isoelectric Point: 5.4707

>T245360 WP_004178299.1 NZ_CP097385:c1569600-1568683 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT245360 WP_004177809.1 NZ_CP097385:c1570364-1569606 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References