Detailed information of TA system TA024536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3878313..3878932
• Replicon: chromosome
• Accession: NC_013757
• Organism: Geodermatophilus obscurus DSM 43160

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D2SCF5
• Locus tag: GOBS_RS18055
• Protein ID: WP_012949708.1
• Coordinates: 3878540..3878932 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GOBS_RS18050
• Protein ID: WP_041241566.1
• Coordinates: 3878313..3878543 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GOBS_RS18030	3873574..3873888	-	315	WP_012949703.1	DUF3303 family protein	-
GOBS_RS18035	3874210..3874455	+	246	WP_012949704.1	Arc family DNA-binding protein	-
GOBS_RS18040	3874452..3874868	+	417	WP_012949705.1	type II toxin-antitoxin system VapC family toxin	-
GOBS_RS18045	3874900..3878148	-	3249	WP_012949706.1	TM0106 family RecB-like putative nuclease	-
GOBS_RS18050	3878313..3878543	+	231	WP_041241566.1	hypothetical protein	Antitoxin
GOBS_RS18055	3878540..3878932	+	393	WP_012949708.1	PIN domain-containing protein	Toxin
GOBS_RS18060	3879227..3879853	-	627	WP_166487719.1	hypothetical protein	-
GOBS_RS18065	3880247..3880609	-	363	WP_012949710.1	cupin domain-containing protein	-
GOBS_RS25660	3880915..3881391	-	477	WP_012949711.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
GOBS_RS18075	3881499..3882467	-	969	WP_012949712.1	endonuclease/exonuclease/phosphatase family protein	-
GOBS_RS18080	3882690..3883058	+	369	WP_166487448.1	hypothetical protein	-
GOBS_RS18085	3883068..3883559	+	492	WP_012949713.1	cupin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (3-116)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13631.56 Da
• Isoelectric Point: 5.4729

>T24536 WP_012949708.1 NC_013757:3878540-3878932 [Geodermatophilus obscurus DSM 43160]
VIVVDASTVVAALLAAGQGGDDAREVMLGDDAHAPHLLDVEVLSAVRRHALSDRLGDTAARDAVTAMRDLPVIRHGHDLL
LDRALQLRDSITAYDGVYVALAEILGATLVTGDRRLSHAPGLRCPVSVVG

Nucleotide

• Length: 393 bp

>T24536 NC_013757:3878540-3878932 [Geodermatophilus obscurus DSM 43160]
GTGATCGTCGTCGATGCCTCGACGGTCGTCGCGGCTCTGCTCGCCGCCGGCCAGGGAGGGGACGACGCCCGCGAGGTGAT
GCTCGGCGACGACGCCCATGCCCCCCACCTGCTCGATGTGGAGGTGCTCTCGGCTGTCCGCCGACACGCATTGAGCGACC
GGCTCGGCGACACGGCTGCCCGGGACGCGGTCACCGCCATGCGCGACCTGCCCGTCATCCGGCACGGCCACGACCTGCTC
CTCGACCGGGCGCTGCAACTGCGCGACTCGATCACCGCCTACGACGGGGTCTACGTCGCGCTGGCCGAGATCCTCGGGGC
CACCCTCGTCACCGGTGACCGCCGGCTGTCCCACGCACCGGGCCTGCGGTGCCCGGTCTCGGTCGTCGGCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8678.01 Da
• Isoelectric Point: 8.7707

>AT24536 WP_041241566.1 NC_013757:3878313-3878543 [Geodermatophilus obscurus DSM 43160]
VSKMLQVRNVPDDLHAELRRRAAEAGMSLSDYVLRELRRVAERSPMAEVFARSAAMRIPLPMDEVVEGIRAERDSR

Nucleotide

• Length: 231 bp

>AT24536 NC_013757:3878313-3878543 [Geodermatophilus obscurus DSM 43160]
GTGAGCAAGATGCTGCAGGTCCGGAACGTGCCGGACGATCTGCACGCCGAACTCCGGCGTCGCGCGGCCGAGGCGGGGAT
GTCCCTGTCCGACTACGTGCTCCGCGAGCTGCGGCGTGTCGCCGAGCGCTCACCGATGGCCGAGGTCTTCGCCCGGTCGG
CGGCGATGCGGATCCCGCTGCCCATGGACGAGGTGGTCGAGGGGATCCGGGCCGAGCGCGACAGCCGGTGA

Structures

Toxin

• AlphaFold DB: D2SCF5