Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1412987..1413503 Replicon chromosome
Accession NZ_CP097385
Organism Klebsiella pneumoniae strain KPTCM

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M6G79_RS06635 Protein ID WP_004178374.1
Coordinates 1412987..1413271 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M6G79_RS06640 Protein ID WP_002886901.1
Coordinates 1413261..1413503 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G79_RS06610 (1408471) 1408471..1408734 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
M6G79_RS06615 (1408864) 1408864..1409037 + 174 WP_032408826.1 hypothetical protein -
M6G79_RS06620 (1409040) 1409040..1409783 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M6G79_RS06625 (1410140) 1410140..1412278 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M6G79_RS06630 (1412519) 1412519..1412983 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M6G79_RS06635 (1412987) 1412987..1413271 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M6G79_RS06640 (1413261) 1413261..1413503 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M6G79_RS06645 (1413581) 1413581..1415491 - 1911 WP_004178373.1 PRD domain-containing protein -
M6G79_RS06650 (1415514) 1415514..1416668 - 1155 WP_004178372.1 lactonase family protein -
M6G79_RS06655 (1416735) 1416735..1417475 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T245359 WP_004178374.1 NZ_CP097385:c1413271-1412987 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245359 WP_002886901.1 NZ_CP097385:c1413503-1413261 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References