Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1317770..1318580 Replicon chromosome
Accession NZ_CP097385
Organism Klebsiella pneumoniae strain KPTCM

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag M6G79_RS06205 Protein ID WP_004178461.1
Coordinates 1317770..1318303 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag M6G79_RS06210 Protein ID WP_002887278.1
Coordinates 1318314..1318580 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G79_RS06200 (1316601) 1316601..1317722 + 1122 WP_002887282.1 cupin domain-containing protein -
M6G79_RS06205 (1317770) 1317770..1318303 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
M6G79_RS06210 (1318314) 1318314..1318580 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
M6G79_RS06215 (1318683) 1318683..1320116 - 1434 WP_004178459.1 Cu(+)/Ag(+) sensor histidine kinase -
M6G79_RS06220 (1320106) 1320106..1320789 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
M6G79_RS06225 (1320961) 1320961..1322346 + 1386 WP_004178457.1 efflux transporter outer membrane subunit -
M6G79_RS06230 (1322364) 1322364..1322708 + 345 WP_004197273.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T245358 WP_004178461.1 NZ_CP097385:c1318303-1317770 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT245358 WP_002887278.1 NZ_CP097385:c1318580-1318314 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References