245355

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5667247..5667833 Replicon chromosome
Accession NZ_CP097383
Organism Pseudomonas aeruginosa strain L00-a

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag M8G39_RS26765 Protein ID WP_003120987.1
Coordinates 5667534..5667833 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag M8G39_RS26760 Protein ID WP_003448662.1
Coordinates 5667247..5667537 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G39_RS26740 (M8G39_26740) 5662398..5662607 + 210 WP_003105733.1 cold-shock protein -
M8G39_RS26745 (M8G39_26745) 5662829..5664718 + 1890 WP_016851610.1 hypothetical protein -
M8G39_RS26750 (M8G39_26750) 5664715..5666691 + 1977 WP_034005499.1 DEAD/DEAH box helicase -
M8G39_RS26755 (M8G39_26755) 5666832..5667176 + 345 WP_016851612.1 hypothetical protein -
M8G39_RS26760 (M8G39_26760) 5667247..5667537 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
M8G39_RS26765 (M8G39_26765) 5667534..5667833 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8G39_RS26770 (M8G39_26770) 5668035..5669159 + 1125 WP_012076859.1 TcpQ domain-containing protein -
M8G39_RS26775 (M8G39_26775) 5669159..5670868 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
M8G39_RS26780 (M8G39_26780) 5670872..5672197 + 1326 WP_031806139.1 type 4b pilus protein PilO2 -
M8G39_RS26785 (M8G39_26785) 5672187..5672720 + 534 WP_023094340.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5640268..5734849 94581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T245355 WP_003120987.1 NZ_CP097383:c5667833-5667534 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT245355 WP_003448662.1 NZ_CP097383:c5667537-5667247 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References