245354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4888004..4889262 Replicon chromosome
Accession NZ_CP097383
Organism Pseudomonas aeruginosa strain L00-a

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag M8G39_RS22935 Protein ID WP_003086331.1
Coordinates 4888004..4888759 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M8G39_RS22940 Protein ID WP_003086329.1
Coordinates 4888894..4889262 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G39_RS22925 (M8G39_22925) 4883175..4885718 + 2544 WP_034005179.1 acyl-homoserine-lactone acylase QuiP -
M8G39_RS22930 (M8G39_22930) 4885873..4887234 - 1362 WP_003081943.1 DNA recombination protein RmuC -
M8G39_RS22935 (M8G39_22935) 4888004..4888759 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
M8G39_RS22940 (M8G39_22940) 4888894..4889262 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M8G39_RS22945 (M8G39_22945) 4889335..4890621 - 1287 WP_033939236.1 FAD-binding oxidoreductase -
M8G39_RS22950 (M8G39_22950) 4890677..4892170 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
M8G39_RS22955 (M8G39_22955) 4892345..4892821 + 477 WP_003140638.1 hypothetical protein -
M8G39_RS22960 (M8G39_22960) 4892824..4893099 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T245354 WP_003086331.1 NZ_CP097383:c4888759-4888004 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT245354 WP_003086329.1 NZ_CP097383:c4889262-4888894 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References