Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3848131..3849352 Replicon chromosome
Accession NZ_CP097383
Organism Pseudomonas aeruginosa strain L00-a

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag M8G39_RS17860 Protein ID WP_003110488.1
Coordinates 3848774..3849352 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M8G39_RS17855 Protein ID WP_003117666.1
Coordinates 3848131..3848685 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G39_RS17830 (M8G39_17830) 3843703..3844254 + 552 WP_003132721.1 XRE family transcriptional regulator -
M8G39_RS17835 (M8G39_17835) 3844251..3844649 - 399 WP_033990114.1 NADH-quinone oxidoreductase subunit A -
M8G39_RS17840 (M8G39_17840) 3844662..3844985 - 324 WP_003102734.1 multidrug efflux SMR transporter -
M8G39_RS17845 (M8G39_17845) 3845316..3845777 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M8G39_RS17850 (M8G39_17850) 3845782..3847977 + 2196 WP_023875495.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M8G39_RS17855 (M8G39_17855) 3848131..3848685 + 555 WP_003117666.1 helix-turn-helix transcriptional regulator Antitoxin
M8G39_RS17860 (M8G39_17860) 3848774..3849352 + 579 WP_003110488.1 HD domain-containing protein Toxin
M8G39_RS17865 (M8G39_17865) 3849462..3850649 - 1188 WP_003139884.1 HlyD family efflux transporter periplasmic adaptor subunit -
M8G39_RS17870 (M8G39_17870) 3850639..3852810 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
M8G39_RS17875 (M8G39_17875) 3852800..3854077 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T245353 WP_003110488.1 NZ_CP097383:3848774-3849352 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.67 Da        Isoelectric Point: 8.5356

>AT245353 WP_003117666.1 NZ_CP097383:3848131-3848685 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADKALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References