Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1965667..1967171 Replicon chromosome
Accession NZ_CP097383
Organism Pseudomonas aeruginosa strain L00-a

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag M8G39_RS09190 Protein ID WP_003119682.1
Coordinates 1965667..1966254 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A9E8LAI1
Locus tag M8G39_RS09195 Protein ID WP_003117606.1
Coordinates 1966317..1967171 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G39_RS09185 (M8G39_09185) 1961922..1965401 - 3480 WP_033938798.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
M8G39_RS09190 (M8G39_09190) 1965667..1966254 + 588 WP_003119682.1 GNAT family protein Toxin
M8G39_RS09195 (M8G39_09195) 1966317..1967171 + 855 WP_003117606.1 AraC family transcriptional regulator Antitoxin
M8G39_RS09200 (M8G39_09200) 1967268..1969433 + 2166 WP_033989266.1 TonB-dependent receptor family protein -
M8G39_RS09205 (M8G39_09205) 1969608..1971482 + 1875 WP_003117607.1 MFS transporter -
M8G39_RS09210 (M8G39_09210) 1971543..1971752 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T245352 WP_003119682.1 NZ_CP097383:1965667-1966254 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31863.14 Da        Isoelectric Point: 7.5295

>AT245352 WP_003117606.1 NZ_CP097383:1966317-1967171 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References