245350

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 151736..152241 Replicon chromosome
Accession NZ_CP097383
Organism Pseudomonas aeruginosa strain L00-a

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M8G39_RS00700 Protein ID WP_003083773.1
Coordinates 151736..152017 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M8G39_RS00705 Protein ID WP_003083775.1
Coordinates 152014..152241 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G39_RS00675 (M8G39_00675) 146987..148336 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
M8G39_RS00680 (M8G39_00680) 148385..149071 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M8G39_RS00685 (M8G39_00685) 149172..149906 + 735 WP_003110658.1 GntR family transcriptional regulator -
M8G39_RS00690 (M8G39_00690) 150086..150496 + 411 WP_003110659.1 aegerolysin family protein -
M8G39_RS00695 (M8G39_00695) 150528..151436 - 909 WP_003083769.1 LysR family transcriptional regulator -
M8G39_RS00700 (M8G39_00700) 151736..152017 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M8G39_RS00705 (M8G39_00705) 152014..152241 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M8G39_RS00710 (M8G39_00710) 152417..153037 - 621 WP_003101226.1 hypothetical protein -
M8G39_RS00715 (M8G39_00715) 153138..153638 + 501 WP_003162763.1 LEA type 2 family protein -
M8G39_RS00720 (M8G39_00720) 153711..154052 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M8G39_RS00725 (M8G39_00725) 154134..155561 - 1428 WP_003083784.1 GABA permease -
M8G39_RS00730 (M8G39_00730) 155730..157223 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T245350 WP_003083773.1 NZ_CP097383:c152017-151736 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT245350 WP_003083775.1 NZ_CP097383:c152241-152014 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References