Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 11512..12071 Replicon plasmid pP14-114
Accession NZ_CP097382
Organism Providencia stuartii strain P14

Toxin (Protein)


Gene name relE Uniprot ID A0A427HAI4
Locus tag M8G38_RS21400 Protein ID WP_038601436.1
Coordinates 11793..12071 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M8G38_RS21395 Protein ID WP_249890932.1
Coordinates 11512..11793 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G38_RS21370 (M8G38_21370) 7285..8025 + 741 WP_282562176.1 type-F conjugative transfer system pilin assembly protein TrbC -
M8G38_RS21375 (M8G38_21375) 7911..9797 + 1887 WP_282562181.1 conjugal transfer protein TraN -
M8G38_RS21380 (M8G38_21380) 9779..10567 + 789 WP_249890931.1 type-F conjugative transfer system pilin assembly protein TraF -
M8G38_RS21385 (M8G38_21385) 10578..10886 + 309 WP_282554873.1 hypothetical protein -
M8G38_RS21390 (M8G38_21390) 10886..11410 + 525 WP_052038320.1 type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB -
M8G38_RS21395 (M8G38_21395) 11512..11793 + 282 WP_249890932.1 ribbon-helix-helix domain-containing protein Antitoxin
M8G38_RS21400 (M8G38_21400) 11793..12071 + 279 WP_038601436.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8G38_RS21405 (M8G38_21405) 12345..12743 + 399 WP_038601438.1 hypothetical protein -
M8G38_RS21410 (M8G38_21410) 12859..13062 + 204 WP_249890933.1 hypothetical protein -
M8G38_RS21415 (M8G38_21415) 13258..14634 + 1377 WP_038601440.1 conjugal transfer pilus assembly protein TraH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..114876 114876


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-50)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10787.42 Da        Isoelectric Point: 8.5045

>T245348 WP_038601436.1 NZ_CP097382:11793-12071 [Providencia stuartii]
MELKWTSKALSDLSRVYDFLAFSNTAAAARVVQTLTQAPVSLLVNNPRMGEQLFQFMPHEVRRVVVANYEVRYEIIDSTI
YILRIWHTREDR

Download         Length: 279 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10401.80 Da        Isoelectric Point: 5.6786

>AT245348 WP_249890932.1 NZ_CP097382:11512-11793 [Providencia stuartii]
MKNSSVPNSTKVLTAHVPLAMADKVDEIAARLERSRGWVMKQALSTWIAQEEMRDTLTREALSDVESGRVIDHQFVQDWA
ASLSSDQPLPVPR

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A427HAI4

Antitoxin

Source ID Structure

References