Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1529218..1529875 Replicon chromosome
Accession NZ_CP097380
Organism Providencia stuartii strain P14

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1H2A7
Locus tag M8G38_RS06755 Protein ID WP_036941148.1
Coordinates 1529465..1529875 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID B2Q1I8
Locus tag M8G38_RS06750 Protein ID WP_004921708.1
Coordinates 1529218..1529484 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G38_RS06735 (M8G38_06735) 1524249..1527125 + 2877 WP_004921716.1 aminomethyl-transferring glycine dehydrogenase -
M8G38_RS06740 (M8G38_06740) 1527344..1527964 - 621 WP_004921714.1 HD domain-containing protein -
M8G38_RS06745 (M8G38_06745) 1527976..1528965 - 990 WP_004921711.1 tRNA-modifying protein YgfZ -
M8G38_RS06750 (M8G38_06750) 1529218..1529484 + 267 WP_004921708.1 FAD assembly factor SdhE Antitoxin
M8G38_RS06755 (M8G38_06755) 1529465..1529875 + 411 WP_036941148.1 protein YgfX Toxin
M8G38_RS06760 (M8G38_06760) 1529921..1530439 - 519 WP_088499135.1 flavodoxin FldB -
M8G38_RS06765 (M8G38_06765) 1530602..1531525 + 924 WP_004921697.1 site-specific tyrosine recombinase XerD -
M8G38_RS06770 (M8G38_06770) 1531545..1532249 + 705 WP_004921696.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M8G38_RS06775 (M8G38_06775) 1532255..1533988 + 1734 WP_004921693.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15289.15 Da        Isoelectric Point: 10.8779

>T245347 WP_036941148.1 NZ_CP097380:1529465-1529875 [Providencia stuartii]
VVLWKSNLSISWKTQLFSTCAHGVVGFILLVAPWAPGNSMVWLPLLVIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWSIVKQPWCSRVGVLLTLSALQGKPQKIRLWVAKDALSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10576.10 Da        Isoelectric Point: 4.9104

>AT245347 WP_004921708.1 NZ_CP097380:1529218-1529484 [Providencia stuartii]
MDIENKARIHWACRRGMRELDISIMPFFEYEYEGLSDKDKRTFVRLLECADPDLFNWLMNHGRPDDDELFGMVKLIQERN
KNRGPVEI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1H2A7

Antitoxin

Source ID Structure
AlphaFold DB A0A140NIX0

References