Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 878296..878947 Replicon chromosome
Accession NZ_CP097380
Organism Providencia stuartii strain P14

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag M8G38_RS03775 Protein ID WP_004927064.1
Coordinates 878296..878499 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B2Q721
Locus tag M8G38_RS03780 Protein ID WP_004927067.1
Coordinates 878579..878947 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G38_RS03750 (M8G38_03750) 874174..874512 + 339 WP_004927053.1 P-II family nitrogen regulator -
M8G38_RS03755 (M8G38_03755) 874523..875806 + 1284 WP_014656764.1 ammonium transporter AmtB -
M8G38_RS03760 (M8G38_03760) 876043..876909 - 867 WP_004927058.1 acyl-CoA thioesterase II -
M8G38_RS03765 (M8G38_03765) 877233..877691 + 459 WP_004927062.1 YbaY family lipoprotein -
M8G38_RS03775 (M8G38_03775) 878296..878499 - 204 WP_004927064.1 HHA domain-containing protein Toxin
M8G38_RS03780 (M8G38_03780) 878579..878947 - 369 WP_004927067.1 Hha toxicity modulator TomB Antitoxin
M8G38_RS03785 (M8G38_03785) 879515..880852 - 1338 WP_004927077.1 murein transglycosylase D -
M8G38_RS03790 (M8G38_03790) 880931..881686 - 756 WP_040132835.1 hydroxyacylglutathione hydrolase -
M8G38_RS03795 (M8G38_03795) 881720..882445 + 726 WP_121874720.1 class I SAM-dependent methyltransferase -
M8G38_RS03800 (M8G38_03800) 882524..882994 - 471 WP_014656762.1 ribonuclease HI -
M8G38_RS03805 (M8G38_03805) 883049..883810 + 762 WP_004927092.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T245346 WP_004927064.1 NZ_CP097380:c878499-878296 [Providencia stuartii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14149.01 Da        Isoelectric Point: 4.2591

>AT245346 WP_004927067.1 NZ_CP097380:c878947-878579 [Providencia stuartii]
MDEYSPKNYDISELKYLCNSLNREAMLSLQKTNTHWVNDLSSPQSARLNELIEHIAAFVWQFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVSVLDDDLKCPASKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A140NKN2

References