245345

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/CC2985(antitoxin)
Location 590495..591030 Replicon chromosome
Accession NZ_CP097380
Organism Providencia stuartii strain P14

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M8G38_RS02545 Protein ID WP_282562126.1
Coordinates 590495..590770 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID B2PVH8
Locus tag M8G38_RS02550 Protein ID WP_004924521.1
Coordinates 590767..591030 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G38_RS02525 (M8G38_02525) 586770..587852 + 1083 WP_004924542.1 alanine racemase -
M8G38_RS02530 (M8G38_02530) 587922..589118 + 1197 WP_014656877.1 amino acid aminotransferase -
M8G38_RS02535 (M8G38_02535) 589177..589713 - 537 Protein_493 transposase -
M8G38_RS02540 (M8G38_02540) 589700..590059 + 360 WP_076914694.1 hypothetical protein -
M8G38_RS02545 (M8G38_02545) 590495..590770 - 276 WP_282562126.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8G38_RS02550 (M8G38_02550) 590767..591030 - 264 WP_004924521.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
M8G38_RS02555 (M8G38_02555) 591049..591447 - 399 WP_282550744.1 hypothetical protein -
M8G38_RS02560 (M8G38_02560) 592021..594855 - 2835 WP_076914695.1 excinuclease ABC subunit UvrA -
M8G38_RS02565 (M8G38_02565) 595245..595760 + 516 WP_154598817.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Antitoxin ParD

(2-74)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10288.90 Da        Isoelectric Point: 5.6925

>T245345 WP_282562126.1 NZ_CP097380:c590770-590495 [Providencia stuartii]
MKLGISPLAVQDLESIGDWIAKDNPIKALSFIEELYQKDSPTLYAERPEILPGLRSCAYGRYLLFFRVLEAEVRIERILH
GSRDIPAHFS

Download         Length: 276 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9432.45 Da        Isoelectric Point: 4.7228

>AT245345 WP_004924521.1 NZ_CP097380:c591030-590767 [Providencia stuartii]
MSTSVALSPYFEEFIQSQIKSGRYNNTSEVIRAGLRALEEQENQLKLAALQTAIVDGINSGESKDASAVFSRLSSKYATL
AEDNGSK

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A140NNC0

References