Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 2046754..2047469 Replicon chromosome
Accession NZ_CP097377
Organism Actinobacillus pleuropneumoniae strain GD2107

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M6G44_RS09720 Protein ID WP_005599445.1
Coordinates 2046754..2047119 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BT01
Locus tag M6G44_RS09725 Protein ID WP_005599447.1
Coordinates 2047182..2047469 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G44_RS09705 (M6G44_09705) 2042339..2044045 - 1707 WP_237593915.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
M6G44_RS09710 (M6G44_09710) 2044141..2044422 - 282 WP_005599441.1 DNA-directed RNA polymerase subunit omega -
M6G44_RS09715 (M6G44_09715) 2044549..2046630 - 2082 WP_237601098.1 ATP-dependent DNA helicase RecG -
M6G44_RS09720 (M6G44_09720) 2046754..2047119 - 366 WP_005599445.1 type II toxin-antitoxin system VapC family toxin Toxin
M6G44_RS09725 (M6G44_09725) 2047182..2047469 - 288 WP_005599447.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M6G44_RS09730 (M6G44_09730) 2047675..2049390 + 1716 WP_005618303.1 proline--tRNA ligase -
M6G44_RS09735 (M6G44_09735) 2049456..2049644 - 189 WP_005618305.1 hypothetical protein -
M6G44_RS09740 (M6G44_09740) 2049647..2050228 - 582 WP_005599450.1 sigma-70 family RNA polymerase sigma factor -
M6G44_RS09745 (M6G44_09745) 2050317..2051273 + 957 WP_005619040.1 protein-methionine-sulfoxide reductase catalytic subunit MsrP -
M6G44_RS09750 (M6G44_09750) 2051273..2051866 + 594 WP_005599453.1 protein-methionine-sulfoxide reductase heme-binding subunit MsrQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13974.06 Da        Isoelectric Point: 9.0549

>T245344 WP_005599445.1 NZ_CP097377:c2047119-2046754 [Actinobacillus pleuropneumoniae]
MDTNVRQWLATIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQAKSFSINNEIALLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNRCDIRLFNPFEPN

Download         Length: 366 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11040.29 Da        Isoelectric Point: 4.5578

>AT245344 WP_005599447.1 NZ_CP097377:c2047469-2047182 [Actinobacillus pleuropneumoniae]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N3C5

References