Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1895154..1895885 Replicon chromosome
Accession NZ_CP097377
Organism Actinobacillus pleuropneumoniae strain GD2107

Toxin (Protein)


Gene name tacT Uniprot ID A0A448U107
Locus tag M6G44_RS08865 Protein ID WP_005602211.1
Coordinates 1895418..1895885 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag M6G44_RS08860 Protein ID WP_005619269.1
Coordinates 1895154..1895414 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G44_RS08840 (M6G44_08840) 1890972..1891865 + 894 WP_005618012.1 site-specific tyrosine recombinase XerD -
M6G44_RS08845 (M6G44_08845) 1891867..1892157 + 291 WP_005602215.1 DUF5389 family protein -
M6G44_RS08850 (M6G44_08850) 1892184..1893443 - 1260 WP_005618010.1 tRNA lysidine(34) synthetase TilS -
M6G44_RS08855 (M6G44_08855) 1893573..1895033 + 1461 WP_237601108.1 metalloprotease TldD -
M6G44_RS08860 (M6G44_08860) 1895154..1895414 + 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
M6G44_RS08865 (M6G44_08865) 1895418..1895885 + 468 WP_005602211.1 GNAT family N-acetyltransferase Toxin
M6G44_RS08870 (M6G44_08870) 1895969..1896850 + 882 WP_012478550.1 50S ribosomal protein L11 methyltransferase -
M6G44_RS08875 (M6G44_08875) 1896917..1897831 - 915 WP_005618000.1 N-acetylmuramic acid 6-phosphate etherase -
M6G44_RS08880 (M6G44_08880) 1897885..1898994 - 1110 WP_005617998.1 anhydro-N-acetylmuramic acid kinase -
M6G44_RS08885 (M6G44_08885) 1899089..1900153 + 1065 WP_012478549.1 MFS transporter -
M6G44_RS08890 (M6G44_08890) 1900156..1900527 + 372 WP_005598830.1 CrcB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17192.19 Da        Isoelectric Point: 8.9312

>T245343 WP_005602211.1 NZ_CP097377:1895418-1895885 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT245343 WP_005619269.1 NZ_CP097377:1895154-1895414 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448U107

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References