Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1678135..1678763 Replicon chromosome
Accession NZ_CP097377
Organism Actinobacillus pleuropneumoniae strain GD2107

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M6G44_RS07820 Protein ID WP_005618201.1
Coordinates 1678135..1678533 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B3GYV7
Locus tag M6G44_RS07825 Protein ID WP_005613300.1
Coordinates 1678533..1678763 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G44_RS07795 (M6G44_07795) 1673757..1674278 + 522 WP_005618211.1 ATP-dependent protease subunit HslV -
M6G44_RS07800 (M6G44_07800) 1674333..1675655 + 1323 WP_005620148.1 HslU--HslV peptidase ATPase subunit -
M6G44_RS07805 (M6G44_07805) 1675728..1676507 + 780 WP_005602546.1 hypothetical protein -
M6G44_RS07810 (M6G44_07810) 1676687..1677337 - 651 WP_005618207.1 DUF2202 domain-containing protein -
M6G44_RS07815 (M6G44_07815) 1677583..1677999 + 417 WP_005618204.1 DUF417 family protein -
M6G44_RS07820 (M6G44_07820) 1678135..1678533 - 399 WP_005618201.1 tRNA(fMet)-specific endonuclease VapC Toxin
M6G44_RS07825 (M6G44_07825) 1678533..1678763 - 231 WP_005613300.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M6G44_RS07830 (M6G44_07830) 1679284..1680915 - 1632 WP_005618198.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1644846..1693445 48599


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-53)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15124.41 Da        Isoelectric Point: 6.9683

>T245342 WP_005618201.1 NZ_CP097377:c1678533-1678135 [Actinobacillus pleuropneumoniae]
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCVSSITAAELYYDAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKCGKILGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Download         Length: 399 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8625.71 Da        Isoelectric Point: 4.5358

>AT245342 WP_005613300.1 NZ_CP097377:c1678763-1678533 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLSSATVSDDFMTEREISTQAEREEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N328

References