Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 1522696..1523341 Replicon chromosome
Accession NZ_CP097377
Organism Actinobacillus pleuropneumoniae strain GD2107

Toxin (Protein)


Gene name toxT Uniprot ID B0BQU7
Locus tag M6G44_RS07050 Protein ID WP_005619674.1
Coordinates 1522970..1523341 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag M6G44_RS07045 Protein ID WP_005598477.1
Coordinates 1522696..1522989 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G44_RS07015 (M6G44_07015) 1518028..1518711 - 684 WP_005605188.1 arginine ABC transporter permease ArtM -
M6G44_RS07020 (M6G44_07020) 1518711..1519382 - 672 WP_005617821.1 arginine ABC transporter permease ArtQ -
M6G44_RS07025 (M6G44_07025) 1519388..1520107 - 720 WP_012478527.1 transporter substrate-binding domain-containing protein -
M6G44_RS07030 (M6G44_07030) 1520127..1520861 - 735 WP_005598473.1 arginine ABC transporter ATP-binding protein ArtP -
M6G44_RS07035 (M6G44_07035) 1521086..1521583 - 498 WP_005617825.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
M6G44_RS07040 (M6G44_07040) 1521656..1522618 + 963 WP_012478528.1 calcium/sodium antiporter -
M6G44_RS07045 (M6G44_07045) 1522696..1522989 - 294 WP_005598477.1 helix-turn-helix domain-containing protein Antitoxin
M6G44_RS07050 (M6G44_07050) 1522970..1523341 - 372 WP_005619674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M6G44_RS07055 (M6G44_07055) 1523535..1525286 + 1752 WP_237601096.1 protein-disulfide reductase DsbD -
M6G44_RS07060 (M6G44_07060) 1525344..1525913 + 570 WP_005608594.1 elongation factor P hydroxylase -
M6G44_RS07065 (M6G44_07065) 1525957..1526811 - 855 WP_005615766.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(32-109)

Antitoxin

(34-85)


Sequences


Toxin        


Download         Length: 124 a.a.        Molecular weight: 15066.57 Da        Isoelectric Point: 10.4054

>T245341 WP_005619674.1 NZ_CP097377:c1523341-1522970 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Download         Length: 372 bp


Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10935.81 Da        Isoelectric Point: 10.3120

>AT245341 WP_005598477.1 NZ_CP097377:c1522989-1522696 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Download         Length: 294 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A3N206


Antitoxin

Source ID Structure

References