Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1436728..1437236 Replicon chromosome
Accession NZ_CP097377
Organism Actinobacillus pleuropneumoniae strain GD2107

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M6G44_RS06595 Protein ID WP_017357690.1
Coordinates 1436976..1437236 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M6G44_RS06590 Protein ID WP_017357689.1
Coordinates 1436728..1436979 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G44_RS06550 (M6G44_06550) 1432263..1432811 - 549 WP_005617759.1 type IV pilus biogenesis/stability protein PilW -
M6G44_RS06555 (M6G44_06555) 1432865..1434046 - 1182 WP_005608495.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
M6G44_RS06580 (M6G44_06580) 1434951..1436390 + 1440 WP_005605060.1 glutamate--tRNA ligase -
M6G44_RS06590 (M6G44_06590) 1436728..1436979 + 252 WP_017357689.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M6G44_RS06595 (M6G44_06595) 1436976..1437236 + 261 WP_017357690.1 Txe/YoeB family addiction module toxin Toxin
M6G44_RS06600 (M6G44_06600) 1437395..1437562 - 168 WP_005598320.1 Trm112 family protein -
M6G44_RS06605 (M6G44_06605) 1437564..1438544 - 981 WP_005598322.1 tetraacyldisaccharide 4'-kinase -
M6G44_RS06610 (M6G44_06610) 1438638..1439897 - 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
M6G44_RS06615 (M6G44_06615) 1439897..1440487 - 591 WP_005601821.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
M6G44_RS06620 (M6G44_06620) 1440609..1441001 + 393 WP_005620423.1 SufE family protein -
M6G44_RS06635 (M6G44_06635) 1441360..1442133 - 774 WP_005618837.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1431165..1432088 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10423.94 Da        Isoelectric Point: 8.0109

>T245340 WP_017357690.1 NZ_CP097377:1436976-1437236 [Actinobacillus pleuropneumoniae]
MKLTFSSNSWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKPEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9336.62 Da        Isoelectric Point: 4.5659

>AT245340 WP_017357689.1 NZ_CP097377:1436728-1436979 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVTEDFEPVLITRSKGGNCVLMSYEQYSSLEETAYLMRSPANAQRLLDSMAELKQGKGIERE
LIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References