Detailed information of TA system TA024534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2014072..2014619
• Replicon: chromosome
• Accession: NC_013757
• Organism: Geodermatophilus obscurus DSM 43160

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D2SEG7
• Locus tag: GOBS_RS09525
• Protein ID: WP_012948078.1
• Coordinates: 2014072..2014347 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GOBS_RS09530
• Protein ID: WP_041242092.1
• Coordinates: 2014344..2014619 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GOBS_RS28090	2009414..2009821	+	408	WP_208104417.1	hypothetical protein	-
GOBS_RS27295	2009763..2010068	+	306	Protein_1908	DUF1338 family protein	-
GOBS_RS25350	2010275..2010841	-	567	WP_049788196.1	hypothetical protein	-
GOBS_RS26190	2010996..2011190	-	195	Protein_1910	LysR family transcriptional regulator	-
GOBS_RS09515	2011291..2012457	+	1167	WP_012948076.1	FAD-binding oxidoreductase	-
GOBS_RS09520	2012474..2014012	+	1539	WP_208104482.1	aldehyde dehydrogenase family protein	-
GOBS_RS09525	2014072..2014347	-	276	WP_012948078.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GOBS_RS09530	2014344..2014619	-	276	WP_041242092.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GOBS_RS09535	2014776..2016992	-	2217	Protein_1915	catalase/peroxidase HPI	-
GOBS_RS09540	2017265..2017651	-	387	WP_041241427.1	hypothetical protein	-
GOBS_RS09545	2017844..2018911	-	1068	WP_012948080.1	non-homologous end-joining DNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (39-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10287.82 Da
• Isoelectric Point: 10.0089

>T24534 WP_012948078.1 NC_013757:c2014347-2014072 [Geodermatophilus obscurus DSM 43160]
VTGPRRHTVVLSAAAKRAIERDLPEPVAVAVVDFLYGPLAADPYRVGKPLRFDLEGYWSARRGQYRVIYSIHDNEVLVRV
VRISHRADVYG

Nucleotide

• Length: 276 bp

>T24534 NC_013757:c2014347-2014072 [Geodermatophilus obscurus DSM 43160]
GTGACCGGCCCTCGTCGCCACACCGTCGTCCTCTCGGCGGCGGCCAAGCGGGCCATCGAGCGAGACCTCCCGGAGCCGGT
GGCTGTCGCGGTCGTCGACTTCCTCTACGGGCCGCTGGCTGCGGATCCGTACCGCGTCGGGAAGCCGCTGCGCTTCGACC
TCGAGGGCTACTGGTCCGCGCGACGAGGCCAGTACCGCGTCATCTACTCGATCCACGACAACGAGGTCCTCGTCAGGGTC
GTGCGCATCTCGCACCGCGCCGACGTCTACGGCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9898.18 Da
• Isoelectric Point: 4.6631

>AT24534 WP_041242092.1 NC_013757:c2014619-2014344 [Geodermatophilus obscurus DSM 43160]
MTTQSLAAVKAHFSQVIDEVAGTHERVTVTKNGSPVAVILAVEDYESLMETLEILSDPRARSDIRQAEELMAAGEVYGEA
EVRAALAARRR

Nucleotide

• Length: 276 bp

>AT24534 NC_013757:c2014619-2014344 [Geodermatophilus obscurus DSM 43160]
ATGACGACGCAGTCGCTGGCGGCGGTCAAGGCGCACTTCAGCCAGGTGATCGACGAGGTCGCCGGCACGCACGAGCGCGT
CACCGTTACCAAGAACGGCAGCCCGGTCGCGGTCATCCTCGCCGTCGAGGACTACGAGTCCCTGATGGAGACCTTGGAGA
TCCTGTCCGATCCTCGAGCGCGGTCGGACATCAGACAGGCCGAGGAATTGATGGCCGCCGGCGAGGTCTACGGCGAGGCC
GAGGTGCGGGCCGCACTCGCGGCCCGCCGGCGGTGA

Structures

Toxin

• AlphaFold DB: D2SEG7