Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 723288..723938 Replicon chromosome
Accession NZ_CP097377
Organism Actinobacillus pleuropneumoniae strain GD2107

Toxin (Protein)


Gene name vapC Uniprot ID B0BNU3
Locus tag M6G44_RS03345 Protein ID WP_005614926.1
Coordinates 723288..723677 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BNU4
Locus tag M6G44_RS03350 Protein ID WP_005604117.1
Coordinates 723678..723938 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G44_RS03330 (M6G44_03330) 718937..720133 + 1197 WP_012478414.1 amino acid aminotransferase -
M6G44_RS03335 (M6G44_03335) 720237..721520 - 1284 WP_005617151.1 Xaa-Pro aminopeptidase -
M6G44_RS03340 (M6G44_03340) 721929..723152 - 1224 WP_005617152.1 ATP-binding protein -
M6G44_RS03345 (M6G44_03345) 723288..723677 - 390 WP_005614926.1 type II toxin-antitoxin system VapC family toxin Toxin
M6G44_RS03350 (M6G44_03350) 723678..723938 - 261 WP_005604117.1 hypothetical protein Antitoxin
M6G44_RS03355 (M6G44_03355) 724072..726093 - 2022 WP_005617154.1 excinuclease ABC subunit UvrB -
M6G44_RS03360 (M6G44_03360) 726270..727082 + 813 WP_005604121.1 iron uptake system protein EfeO -
M6G44_RS03365 (M6G44_03365) 727094..728287 + 1194 WP_237601177.1 iron uptake transporter deferrochelatase/peroxidase subunit -
M6G44_RS03370 (M6G44_03370) 728298..728918 + 621 WP_005596976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14837.17 Da        Isoelectric Point: 5.1295

>T245339 WP_005614926.1 NZ_CP097377:c723677-723288 [Actinobacillus pleuropneumoniae]
MYMLDTNTVSYFFRQDPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMEREGKIMGVQDQMIGAHALATECVLVSSDKAFQFIPNLVLENWWK

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10289.63 Da        Isoelectric Point: 5.1867

>AT245339 WP_005604117.1 NZ_CP097377:c723938-723678 [Actinobacillus pleuropneumoniae]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEQERKQEMATR
DPFEGF

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3N029

Antitoxin

Source ID Structure
AlphaFold DB A3N030

References