Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3788235..3788724 Replicon chromosome
Accession NZ_CP097376
Organism Eubacterium limosum strain B2

Toxin (Protein)


Gene name relE Uniprot ID A0A317S0V5
Locus tag M5595_RS17980 Protein ID WP_038352201.1
Coordinates 3788449..3788724 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A317RXL4
Locus tag M5595_RS17975 Protein ID WP_038352202.1
Coordinates 3788235..3788456 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5595_RS17950 (M5595_17950) 3783539..3783691 + 153 WP_167617884.1 hypothetical protein -
M5595_RS17955 (M5595_17955) 3783830..3784324 + 495 WP_038352206.1 hypothetical protein -
M5595_RS17960 (M5595_17960) 3784355..3785848 - 1494 WP_038352205.1 glycerol kinase GlpK -
M5595_RS17965 (M5595_17965) 3785860..3787395 - 1536 WP_038352204.1 amidohydrolase -
M5595_RS17970 (M5595_17970) 3787400..3787975 - 576 WP_167617886.1 glycerol-3-phosphate responsive antiterminator -
M5595_RS17975 (M5595_17975) 3788235..3788456 + 222 WP_038352202.1 DUF6290 family protein Antitoxin
M5595_RS17980 (M5595_17980) 3788449..3788724 + 276 WP_038352201.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5595_RS17985 (M5595_17985) 3788845..3792216 + 3372 WP_038352200.1 exodeoxyribonuclease V subunit gamma -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-89)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10646.43 Da        Isoelectric Point: 10.1275

>T245338 WP_038352201.1 NZ_CP097376:3788449-3788724 [Eubacterium limosum]
MAEKYHVVLTEKAKKSLKKLDKHTALLITAWLRKNLEGCTDPYQYGKGLTANRSGQWRYRIGDYRLVCEISEQTITILVL
NIGHRKEIYKH

Download         Length: 276 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8523.66 Da        Isoelectric Point: 4.1285

>AT245338 WP_038352202.1 NZ_CP097376:3788235-3788456 [Eubacterium limosum]
MAVSLRLNKEDEALIRSYAEMKNLSVSEAIRQAIMEKIEDEFDLKVYYEAMTEYKENPVTYTLDEVERELGLG

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A317S0V5

Antitoxin

Source ID Structure
AlphaFold DB A0A317RXL4

References