Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 530075..530711 Replicon chromosome
Accession NZ_CP097373
Organism Bacillus safensis strain AHB2

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag M5E02_RS02580 Protein ID WP_024425388.1
Coordinates 530361..530711 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag M5E02_RS02575 Protein ID WP_003214273.1
Coordinates 530075..530356 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5E02_RS02555 (M5E02_02555) 526218..526823 - 606 WP_252057397.1 rhomboid family intramembrane serine protease -
M5E02_RS02560 (M5E02_02560) 526918..527283 + 366 WP_252057399.1 holo-ACP synthase -
M5E02_RS02565 (M5E02_02565) 527444..528460 + 1017 WP_095407802.1 outer membrane lipoprotein carrier protein LolA -
M5E02_RS02570 (M5E02_02570) 528600..529781 + 1182 WP_252057401.1 alanine racemase -
M5E02_RS02575 (M5E02_02575) 530075..530356 + 282 WP_003214273.1 hypothetical protein Antitoxin
M5E02_RS02580 (M5E02_02580) 530361..530711 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
M5E02_RS02585 (M5E02_02585) 530828..531658 + 831 WP_252057403.1 RsbT co-antagonist protein RsbRA -
M5E02_RS02590 (M5E02_02590) 531663..532031 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
M5E02_RS02595 (M5E02_02595) 532034..532435 + 402 WP_024427376.1 anti-sigma regulatory factor -
M5E02_RS02600 (M5E02_02600) 532446..533453 + 1008 WP_041089208.1 PP2C family protein-serine/threonine phosphatase -
M5E02_RS02605 (M5E02_02605) 533513..533842 + 330 WP_017358393.1 anti-sigma factor antagonist -
M5E02_RS02610 (M5E02_02610) 533839..534327 + 489 WP_048240335.1 anti-sigma B factor RsbW -
M5E02_RS02615 (M5E02_02615) 534293..535081 + 789 WP_048240336.1 RNA polymerase sigma factor SigB -
M5E02_RS02620 (M5E02_02620) 535081..535680 + 600 WP_048240337.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T245336 WP_024425388.1 NZ_CP097373:530361-530711 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT245336 WP_003214273.1 NZ_CP097373:530075-530356 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References