Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4314737..4315234 Replicon chromosome
Accession NZ_CP097370
Organism Escherichia coli strain AGR5151

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag M7748_RS20845 Protein ID WP_001173343.1
Coordinates 4314737..4314910 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag M7748_RS20850 Protein ID WP_001312331.1
Coordinates 4314938..4315234 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7748_RS20835 (4311407) 4311407..4312864 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
M7748_RS20840 (4313101) 4313101..4314618 + 1518 WP_000003806.1 lysine--tRNA ligase -
M7748_RS20845 (4314737) 4314737..4314910 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
M7748_RS20850 (4314938) 4314938..4315234 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
M7748_RS20855 (4315462) 4315462..4315734 - 273 WP_000405643.1 GNAT family N-acetyltransferase -
M7748_RS20860 (4315948) 4315948..4319877 - 3930 WP_001080127.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4314737..4330917 16180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T245332 WP_001173343.1 NZ_CP097370:c4314910-4314737 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT245332 WP_001312331.1 NZ_CP097370:c4315234-4314938 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References