Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1725831..1726462 Replicon chromosome
Accession NC_013757
Organism Geodermatophilus obscurus DSM 43160

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GOBS_RS08235 Protein ID WP_041241403.1
Coordinates 1726058..1726462 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GOBS_RS08230 Protein ID WP_166487334.1
Coordinates 1725831..1726061 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOBS_RS08200 1720861..1721778 + 918 WP_012947818.1 GTPase Era -
GOBS_RS08205 1721778..1722569 + 792 WP_012947819.1 DNA repair protein RecO -
GOBS_RS08210 1722559..1723323 + 765 WP_041241401.1 isoprenyl transferase -
GOBS_RS08215 1723389..1723682 + 294 WP_012947821.1 antibiotic biosynthesis monooxygenase -
GOBS_RS08220 1723835..1724176 + 342 WP_166487333.1 hypothetical protein -
GOBS_RS08225 1724326..1725744 + 1419 WP_049788175.1 glycine--tRNA ligase -
GOBS_RS08230 1725831..1726061 + 231 WP_166487334.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GOBS_RS08235 1726058..1726462 + 405 WP_041241403.1 PIN domain nuclease Toxin
GOBS_RS08240 1726777..1727949 + 1173 WP_041242027.1 tRNA dihydrouridine synthase DusB -
GOBS_RS08245 1727955..1728401 + 447 WP_012947827.1 hypothetical protein -
GOBS_RS08250 1728708..1731419 + 2712 WP_012947828.1 pyruvate, phosphate dikinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-34)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14672.63 Da        Isoelectric Point: 4.9811

>T24533 WP_041241403.1 NC_013757:1726058-1726462 [Geodermatophilus obscurus DSM 43160]
VTVLVDSSVWIAFLRDSGGPEVDLLEQLIDERRAATTDVVLLEVLAGTTDEERAARLRRFLAGAELLRQESPVDAEQAAA
LHRACRRAGETPRSLNDCLIAAVALRHDVPVLHRDRDFTVLAQHTDLRLVGSAA

Download         Length: 405 bp

>T24533 NC_013757:1726058-1726462 [Geodermatophilus obscurus DSM 43160]
GTGACCGTCCTCGTCGACTCCTCCGTGTGGATCGCCTTCCTCCGGGACTCCGGTGGCCCTGAGGTCGACCTGCTGGAACA
GCTCATCGACGAGCGGCGAGCGGCAACCACGGATGTCGTGCTGCTCGAGGTGCTCGCCGGTACCACCGACGAGGAGCGCG
CAGCGCGCCTGCGGCGCTTCCTCGCAGGCGCGGAACTGCTCCGCCAGGAGTCGCCCGTGGACGCCGAGCAAGCGGCCGCC
CTCCACCGGGCGTGCCGGCGAGCAGGTGAGACGCCCCGGTCGCTCAACGACTGCCTCATCGCCGCGGTCGCACTGCGGCA
CGACGTGCCCGTGCTCCACCGGGACCGGGACTTCACCGTGCTGGCACAGCACACGGACCTGCGGCTGGTGGGGTCGGCGG
CCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8350.38 Da        Isoelectric Point: 4.7377

>AT24533 WP_166487334.1 NC_013757:1725831-1726061 [Geodermatophilus obscurus DSM 43160]
VSRTNIDIDDDLIAGVMRRYGLATKKDAVDFALRQVSVVPMTAREMHAMRGSGWGADLEDLRTREGAEVSAQWGEG

Download         Length: 231 bp

>AT24533 NC_013757:1725831-1726061 [Geodermatophilus obscurus DSM 43160]
GTGAGCCGGACGAACATCGACATCGACGACGACCTCATCGCCGGTGTCATGCGCCGCTACGGGTTGGCGACGAAGAAGGA
CGCCGTCGACTTCGCCCTCCGCCAGGTGTCCGTCGTGCCGATGACGGCGCGCGAGATGCACGCGATGCGCGGCAGCGGCT
GGGGAGCGGACCTTGAGGACCTCCGGACCCGTGAGGGTGCGGAGGTCAGCGCTCAGTGGGGCGAGGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References