Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3513185..3513803 Replicon chromosome
Accession NZ_CP097370
Organism Escherichia coli strain AGR5151

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M7748_RS16950 Protein ID WP_001291435.1
Coordinates 3513585..3513803 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M7748_RS16945 Protein ID WP_000344800.1
Coordinates 3513185..3513559 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7748_RS16935 (3508274) 3508274..3509467 + 1194 WP_250024141.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M7748_RS16940 (3509490) 3509490..3512639 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
M7748_RS16945 (3513185) 3513185..3513559 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M7748_RS16950 (3513585) 3513585..3513803 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M7748_RS16955 (3513976) 3513976..3514527 + 552 WP_000102539.1 maltose O-acetyltransferase -
M7748_RS16960 (3514643) 3514643..3515113 + 471 WP_000136192.1 YlaC family protein -
M7748_RS16965 (3515277) 3515277..3516827 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M7748_RS16970 (3516869) 3516869..3517222 - 354 WP_000878147.1 DUF1428 family protein -
M7748_RS16980 (3517601) 3517601..3517912 + 312 WP_000409908.1 MGMT family protein -
M7748_RS16985 (3517943) 3517943..3518515 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T245327 WP_001291435.1 NZ_CP097370:3513585-3513803 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT245327 WP_000344800.1 NZ_CP097370:3513185-3513559 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References