Detailed information of TA system TA024532

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 850535..851199
• Replicon: chromosome
• Accession: NC_013757
• Organism: Geodermatophilus obscurus DSM 43160

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D2S8D9
• Locus tag: GOBS_RS03955
• Protein ID: WP_012947002.1
• Coordinates: 850535..850927 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D2S8E0
• Locus tag: GOBS_RS03960
• Protein ID: WP_012947003.1
• Coordinates: 850924..851199 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GOBS_RS03950	848542..850338	-	1797	WP_012947001.1	DEAD/DEAH box helicase family protein	-
GOBS_RS03955	850535..850927	-	393	WP_012947002.1	type II toxin-antitoxin system VapC family toxin	Toxin
GOBS_RS03960	850924..851199	-	276	WP_012947003.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GOBS_RS25170	851239..852087	-	849	WP_012947004.1	CPBP family intramembrane metalloprotease	-
GOBS_RS03970	852117..853004	-	888	WP_166487554.1	CPBP family intramembrane metalloprotease	-
GOBS_RS03975	853039..853353	-	315	WP_012947006.1	hypothetical protein	-
GOBS_RS03980	853457..855724	+	2268	WP_012947007.1	LuxR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-41)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13327.35 Da
• Isoelectric Point: 4.3402

>T24532 WP_012947002.1 NC_013757:c850927-850535 [Geodermatophilus obscurus DSM 43160]
VIAIDSSALVKLVLDEPESAALEGWLTSRAPLSVAASDLVRVELIRAVARAAPAGVPRARTLLTGVDLVPVTRDLLETAA
DLGPPSLRSLDALHLATALSLGSALDAFVVYDERLAQAATDAGLPVVAPS

Nucleotide

• Length: 393 bp

>T24532 NC_013757:c850927-850535 [Geodermatophilus obscurus DSM 43160]
GTGATCGCGATCGACTCCTCCGCCCTCGTGAAACTGGTGCTCGACGAGCCGGAGTCGGCAGCACTGGAGGGGTGGCTGAC
CAGTCGGGCCCCGCTCTCGGTCGCGGCCAGCGACCTGGTGAGGGTCGAGCTGATCCGTGCCGTGGCCCGCGCCGCCCCTG
CCGGCGTGCCCCGAGCCCGGACACTCCTGACCGGGGTGGACCTGGTCCCGGTCACCCGGGACCTGCTCGAGACGGCCGCC
GATCTCGGACCGCCGTCCTTGCGCAGCCTGGACGCGCTCCACCTGGCGACGGCCCTGAGCCTCGGGTCGGCTCTGGACGC
CTTCGTGGTGTACGACGAGCGGCTGGCGCAGGCAGCCACCGACGCGGGGCTGCCGGTCGTCGCGCCGTCCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9814.25 Da
• Isoelectric Point: 8.7490

>AT24532 WP_012947003.1 NC_013757:c851199-850924 [Geodermatophilus obscurus DSM 43160]
MTRIGVRELRQNASRYLALVKAGETVEVTERGELIAVLSPPSPAATTRERLIAEGRLVPASAPFRIPDRVPPPAGALSAS
EALDEQRAERL

Nucleotide

• Length: 276 bp

>AT24532 NC_013757:c851199-850924 [Geodermatophilus obscurus DSM 43160]
ATGACCCGCATCGGGGTGCGCGAGCTGCGGCAGAACGCGAGTCGGTACCTGGCGCTCGTCAAGGCCGGCGAGACGGTCGA
GGTGACCGAGCGCGGTGAGCTCATCGCGGTCCTGTCCCCGCCGTCCCCCGCGGCGACGACACGTGAGCGGCTGATCGCCG
AAGGGCGGCTGGTCCCCGCCAGCGCTCCGTTCCGCATTCCCGACCGGGTTCCGCCTCCAGCCGGAGCGCTCAGCGCGTCC
GAGGCTCTCGACGAGCAGCGCGCCGAGCGCTTGTGA

Structures

Toxin

• AlphaFold DB: D2S8D9

Antitoxin

• AlphaFold DB: D2S8E0