Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 45959..46794 Replicon chromosome
Accession NZ_CP097370
Organism Escherichia coli strain AGR5151

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag M7748_RS00240 Protein ID WP_001094448.1
Coordinates 45959..46336 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T7EC32
Locus tag M7748_RS00245 Protein ID WP_024175935.1
Coordinates 46426..46794 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7748_RS00210 (41327) 41327..42145 + 819 WP_000779409.1 lipoprotein NlpA -
M7748_RS00215 (42149) 42149..43072 - 924 WP_000535950.1 carboxylate/amino acid/amine transporter -
M7748_RS00220 (43250) 43250..43747 - 498 WP_000509815.1 hypothetical protein -
M7748_RS00225 (44340) 44340..45185 - 846 WP_001576423.1 DUF4942 domain-containing protein -
M7748_RS00230 (45270) 45270..45462 - 193 Protein_45 hypothetical protein -
M7748_RS00235 (45474) 45474..45962 - 489 WP_000761714.1 DUF5983 family protein -
M7748_RS00240 (45959) 45959..46336 - 378 WP_001094448.1 TA system toxin CbtA family protein Toxin
M7748_RS00245 (46426) 46426..46794 - 369 WP_024175935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M7748_RS00250 (46868) 46868..47053 - 186 Protein_49 DUF987 family protein -
M7748_RS00255 (47059) 47059..47535 - 477 WP_001618155.1 RadC family protein -
M7748_RS00260 (47547) 47547..48032 - 486 WP_000214415.1 antirestriction protein -
M7748_RS00265 (48124) 48124..48942 - 819 WP_001234753.1 DUF932 domain-containing protein -
M7748_RS00270 (49033) 49033..49266 - 234 WP_001117568.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 45959..55115 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T245313 WP_001094448.1 NZ_CP097370:c46336-45959 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13598.40 Da        Isoelectric Point: 6.6255

>AT245313 WP_024175935.1 NZ_CP097370:c46794-46426 [Escherichia coli]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376WVB1

Antitoxin

Source ID Structure
AlphaFold DB A0A3T7EC32

References