245312

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 113779..114380 Replicon plasmid pAGR6128
Accession NZ_CP097368
Organism Escherichia coli strain AGR6128

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag M7747_RS24250 Protein ID WP_001216034.1
Coordinates 114000..114380 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag M7747_RS24245 Protein ID WP_001190712.1
Coordinates 113779..114000 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7747_RS24235 (110772) 110772..112043 - 1272 WP_023142242.1 restriction endonuclease subunit S -
M7747_RS24240 (112040) 112040..113596 - 1557 WP_001617892.1 type I restriction-modification system subunit M -
M7747_RS24245 (113779) 113779..114000 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M7747_RS24250 (114000) 114000..114380 + 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
M7747_RS24255 (114385) 114385..114564 + 180 WP_001513661.1 hypothetical protein -
M7747_RS24260 (114592) 114592..114870 + 279 Protein_130 pdcB -
M7747_RS24265 (114875) 114875..115288 + 414 Protein_131 integrase core domain-containing protein -
M7747_RS24270 (115238) 115238..115573 - 336 WP_169329198.1 type I deoxyribonuclease HsdR -
M7747_RS24275 (115783) 115783..116763 - 981 WP_000019407.1 IS5-like element IS5 family transposase -
M7747_RS24280 (117007) 117007..118410 + 1404 WP_001373486.1 S-methylmethionine permease -
M7747_RS24285 (118397) 118397..119329 + 933 WP_000081352.1 homocysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA17 / aadA5 / qacE / sul1 / mph(A) / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / blaCTX-M-27 senB 1..122671 122671


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T245312 WP_001216034.1 NZ_CP097368:114000-114380 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT245312 WP_001190712.1 NZ_CP097368:113779-114000 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References