Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4051678..4052254 Replicon chromosome
Accession NZ_CP097367
Organism Escherichia coli strain AGR6128

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag M7747_RS19755 Protein ID WP_001297643.1
Coordinates 4051967..4052254 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag M7747_RS19750 Protein ID WP_000063156.1
Coordinates 4051678..4051980 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7747_RS19735 (4048274) 4048274..4050424 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
M7747_RS19740 (4050474) 4050474..4050677 + 204 WP_000467859.1 YbdD/YjiX family protein -
M7747_RS19745 (4050688) 4050688..4051644 + 957 WP_001297640.1 GTPase -
M7747_RS19750 (4051678) 4051678..4051980 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
M7747_RS19755 (4051967) 4051967..4052254 - 288 WP_001297643.1 BrnT family toxin Toxin
M7747_RS19760 (4052453) 4052453..4053150 - 698 Protein_3870 IS1 family transposase -
M7747_RS19765 (4053207) 4053207..4053302 + 96 Protein_3871 dienelactone hydrolase family protein -
M7747_RS19770 (4053448) 4053448..4054680 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
M7747_RS19775 (4054721) 4054721..4056001 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T245304 WP_001297643.1 NZ_CP097367:c4052254-4051967 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT245304 WP_000063156.1 NZ_CP097367:c4051980-4051678 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References