245303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3941967..3942517 Replicon chromosome
Accession NZ_CP097367
Organism Escherichia coli strain AGR6128

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag M7747_RS19215 Protein ID WP_001160966.1
Coordinates 3941967..3942281 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag M7747_RS19220 Protein ID WP_000125566.1
Coordinates 3942284..3942517 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7747_RS19190 (3937642) 3937642..3938928 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
M7747_RS19195 (3938928) 3938928..3939917 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
M7747_RS19200 (3939914) 3939914..3940735 + 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
M7747_RS19205 (3940738) 3940738..3941115 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
M7747_RS19210 (3941122) 3941122..3941970 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
M7747_RS19215 (3941967) 3941967..3942281 - 315 WP_001160966.1 CcdB family protein Toxin
M7747_RS19220 (3942284) 3942284..3942517 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
M7747_RS19225 (3942603) 3942603..3943082 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
M7747_RS19230 (3943274) 3943274..3945136 - 1863 WP_000377124.1 glutathione-regulated potassium-efflux system protein KefC -
M7747_RS19235 (3945129) 3945129..3945659 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
M7747_RS19240 (3945767) 3945767..3947098 - 1332 WP_001183207.1 MFS transporter -
M7747_RS19245 (3947157) 3947157..3947444 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T245303 WP_001160966.1 NZ_CP097367:c3942281-3941967 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT245303 WP_000125566.1 NZ_CP097367:c3942517-3942284 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References