Detailed information of TA system TA245302

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3712434..3714123
• Replicon: chromosome
• Accession: NZ_CP097367
• Organism: Escherichia coli strain AGR6128

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: M7747_RS18140
• Protein ID: WP_000365807.1
• Coordinates: 3712434..3713354 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: M7747_RS18145
• Protein ID: WP_001295795.1
• Coordinates: 3713341..3714123 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M7747_RS18100 (3707907)	3707907..3708617	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
M7747_RS18105 (3708924)	3708924..3709253	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
M7747_RS18110 (3709265)	3709265..3709431	-	167	Protein_3551	tail fiber assembly protein	-
M7747_RS18115 (3709502)	3709502..3710116	-	615	WP_001019923.1	YagU family protein	-
M7747_RS18120 (3710331)	3710331..3710516	-	186	WP_000146240.1	hypothetical protein	-
M7747_RS18125 (3710565)	3710565..3710723	+	159	Protein_3554	integrase	-
M7747_RS18130 (3710950)	3710950..3711285	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
M7747_RS18135 (3711493)	3711493..3712269	+	777	WP_000171155.1	site-specific integrase	-
M7747_RS18140 (3712434)	3712434..3713354	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M7747_RS18145 (3713341)	3713341..3714123	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
M7747_RS18150 (3714407)	3714407..3717505	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3678380..3721186	42806

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T245302 WP_000365807.1 NZ_CP097367:c3713354-3712434 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT245302 WP_001295795.1 NZ_CP097367:c3714123-3713341 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0