Detailed information of TA system TA024530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 3171992..3172658
• Replicon: chromosome
• Accession: NC_013739
• Organism: Conexibacter woesei DSM 14684

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CWOE_RS14800
• Protein ID: WP_012934437.1
• Coordinates: 3172257..3172658 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D3FBX0
• Locus tag: CWOE_RS14795
• Protein ID: WP_012934436.1
• Coordinates: 3171992..3172267 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWOE_RS14770	3167069..3168241	-	1173	WP_012934431.1	exonuclease SbcCD subunit D	-
CWOE_RS14775	3168295..3168774	-	480	WP_012934432.1	hypothetical protein	-
CWOE_RS14780	3168824..3169060	-	237	WP_012934433.1	hypothetical protein	-
CWOE_RS14785	3169144..3171237	+	2094	WP_012934434.1	phage holin family protein	-
CWOE_RS14790	3171165..3171923	-	759	WP_012934435.1	MBL fold metallo-hydrolase	-
CWOE_RS14795	3171992..3172267	+	276	WP_012934436.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CWOE_RS14800	3172257..3172658	+	402	WP_012934437.1	type II toxin-antitoxin system VapC family toxin	Toxin
CWOE_RS14805	3172669..3173523	-	855	WP_012934438.1	fused MFS/spermidine synthase	-
CWOE_RS14810	3173592..3174119	-	528	WP_012934439.1	ribonuclease HI	-
CWOE_RS14815	3174236..3174919	-	684	WP_012934440.1	hypothetical protein	-
CWOE_RS14820	3175031..3175801	+	771	WP_012934441.1	nucleotidyltransferase domain-containing protein	-
CWOE_RS14825	3175850..3176317	-	468	WP_012934442.1	metal-dependent transcriptional regulator	-
CWOE_RS14830	3176380..3176730	-	351	WP_012934443.1	helix-turn-helix transcriptional regulator	-
CWOE_RS14835	3176749..3177582	-	834	WP_012934444.1	NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14273.40 Da
• Isoelectric Point: 5.5536

>T24530 WP_012934437.1 NC_013739:3172257-3172658 [Conexibacter woesei DSM 14684]
MSADAVCYLDSSALVKLVVREPESATLTRHLRSRPVRVSCALATVEVVRAVGAHGPEATDRARQVLDGVDMIRLDDPLLH
AAATLDGPLLRSLDAIHLAAALALREDEVELITYDRRMAAHAEQLGFVVSAPA

Nucleotide

• Length: 402 bp

>T24530 NC_013739:3172257-3172658 [Conexibacter woesei DSM 14684]
ATGAGCGCTGACGCCGTTTGCTATCTCGACTCGTCGGCGCTCGTGAAGCTGGTCGTGCGGGAGCCGGAGTCGGCGACGCT
CACCCGTCATCTGCGCTCACGGCCGGTCCGCGTCTCGTGTGCGCTGGCGACCGTGGAAGTCGTCCGCGCGGTAGGCGCGC
ACGGCCCCGAAGCGACCGATCGTGCGCGCCAGGTCCTCGACGGCGTCGACATGATCCGGCTCGACGATCCGCTGCTGCAC
GCCGCCGCGACGCTTGACGGCCCATTGCTTCGCAGCCTCGATGCGATCCACCTCGCCGCTGCGCTCGCGTTGCGGGAGGA
CGAGGTCGAGCTGATCACCTACGACCGCCGCATGGCCGCGCACGCGGAGCAGCTCGGCTTCGTCGTCTCAGCGCCGGCCT
GA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9996.30 Da
• Isoelectric Point: 8.7873

>AT24530 WP_012934436.1 NC_013739:3171992-3172267 [Conexibacter woesei DSM 14684]
MRSIGIRELRQQASRYLREVERGETFEVTDRGRPVALLAPVPQASTVERLAASGRLRRASGDVLALGEPLAPAAGISTPS
ETLERLRDDER

Nucleotide

• Length: 276 bp

>AT24530 NC_013739:3171992-3172267 [Conexibacter woesei DSM 14684]
ATGCGTTCGATCGGCATCAGAGAGCTGCGGCAGCAGGCGAGCCGCTACCTGCGGGAGGTCGAGCGCGGGGAGACGTTCGA
GGTGACCGATCGCGGCCGCCCGGTCGCGCTGCTTGCTCCCGTACCCCAGGCAAGCACGGTCGAGCGGCTCGCGGCGAGCG
GGCGGCTCCGCCGCGCGAGCGGCGACGTGCTCGCACTCGGCGAGCCGCTCGCGCCCGCAGCGGGCATCTCGACGCCGAGC
GAGACGCTCGAGCGACTCCGCGACGATGAGCGCTGA

Structures

Antitoxin

• AlphaFold DB: D3FBX0