245290

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 817600..818881 Replicon chromosome
Accession NZ_CP097367
Organism Escherichia coli strain AGR6128

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag M7747_RS03975 Protein ID WP_001114681.1
Coordinates 817600..818493 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag M7747_RS03980 Protein ID WP_000208383.1
Coordinates 818486..818881 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7747_RS03960 (813949) 813949..815097 - 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -
M7747_RS03965 (815169) 815169..816152 - 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
M7747_RS03970 (816959) 816959..817129 - 171 Protein_780 IS110 family transposase -
M7747_RS03975 (817600) 817600..818493 - 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M7747_RS03980 (818486) 818486..818881 - 396 WP_000208383.1 DUF6088 family protein Antitoxin
M7747_RS03985 (818950) 818950..819795 - 846 WP_001529401.1 DUF4942 domain-containing protein -
M7747_RS03990 (819880) 819880..820077 - 198 WP_000839293.1 DUF957 domain-containing protein -
M7747_RS03995 (820094) 820094..820582 - 489 WP_000761699.1 DUF5983 family protein -
M7747_RS04000 (820579) 820579..820956 - 378 WP_000854690.1 TA system toxin CbtA family protein -
M7747_RS04005 (821045) 821045..821413 - 369 WP_001305076.1 type IV toxin-antitoxin system YeeU family antitoxin -
M7747_RS04010 (821463) 821463..822107 - 645 WP_000094916.1 hypothetical protein -
M7747_RS04015 (822126) 822126..822347 - 222 WP_000692329.1 DUF987 domain-containing protein -
M7747_RS04020 (822410) 822410..822886 - 477 WP_001186726.1 RadC family protein -
M7747_RS04025 (822902) 822902..823387 - 486 WP_000849565.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / sat 800622..869625 69003
- flank IS/Tn - - 816959..817114 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T245290 WP_001114681.1 NZ_CP097367:c818493-817600 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT245290 WP_000208383.1 NZ_CP097367:c818881-818486 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References