Detailed information of TA system TA024529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 888469..889022
• Replicon: chromosome
• Accession: NC_013739
• Organism: Conexibacter woesei DSM 14684

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D3FAL1
• Locus tag: CWOE_RS04240
• Protein ID: WP_012932333.1
• Coordinates: 888469..888744 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CWOE_RS04245
• Protein ID: WP_201447138.1
• Coordinates: 888741..889022 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWOE_RS04215	883668..885320	-	1653	WP_012932329.1	methylmalonyl-CoA mutase family protein	-
CWOE_RS04220	885433..886290	+	858	WP_012932330.1	3-hydroxybutyryl-CoA dehydrogenase	-
CWOE_RS04225	886295..886615	-	321	WP_012932331.1	hypothetical protein	-
CWOE_RS04230	886699..888138	-	1440	WP_012932332.1	cytochrome P450	-
CWOE_RS04240	888469..888744	-	276	WP_012932333.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CWOE_RS04245	888741..889022	-	282	WP_201447138.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CWOE_RS32475	889078..889257	-	180	WP_148260890.1	hypothetical protein	-
CWOE_RS04250	889578..890399	+	822	WP_012932336.1	NAD(P)-dependent oxidoreductase	-
CWOE_RS04255	890459..890809	+	351	WP_012932337.1	helix-turn-helix transcriptional regulator	-
CWOE_RS04260	891181..891504	-	324	WP_012932338.1	YnfA family protein	-
CWOE_RS04265	891702..892433	-	732	WP_160165471.1	cadmium resistance transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (14-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-74)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10266.67 Da
• Isoelectric Point: 9.5564

>T24529 WP_012932333.1 NC_013739:c888744-888469 [Conexibacter woesei DSM 14684]
VSEQEPWRLTVAGPAARDIQRLPEKYATAIVEALAHIAENPRRLGKPLRLELDGHWSAGRGPYRIIYTLDDAERTVQVVA
VAHRADAYRPR

Nucleotide

• Length: 276 bp

>T24529 NC_013739:c888744-888469 [Conexibacter woesei DSM 14684]
GTGAGCGAGCAGGAGCCCTGGCGCCTCACGGTCGCCGGCCCCGCAGCGCGCGACATCCAGCGCTTGCCCGAAAAGTACGC
AACGGCGATAGTCGAGGCACTCGCGCACATCGCCGAGAACCCGCGACGCCTCGGCAAGCCACTCCGCCTCGAACTCGATG
GCCACTGGTCAGCCGGGCGTGGGCCATACCGAATCATCTACACGCTCGATGACGCCGAGCGCACCGTCCAGGTCGTCGCG
GTCGCGCATCGAGCCGACGCGTACCGCCCTCGGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 9935.19 Da
• Isoelectric Point: 4.3016

>AT24529 WP_201447138.1 NC_013739:c889022-888741 [Conexibacter woesei DSM 14684]
MSETLPLSAVKSHLSELVDRVEGQHDRVVVTRNGRPAAVLISPDDLESLEETLAILSDRAMMEKVREGDAAIAAGDSISL
EELRAQLGQSPAA

Nucleotide

• Length: 282 bp

>AT24529 NC_013739:c889022-888741 [Conexibacter woesei DSM 14684]
ATGTCCGAGACGCTGCCGCTCTCCGCCGTCAAGTCCCACCTCTCTGAGCTGGTCGACCGCGTCGAAGGCCAACACGACCG
CGTCGTCGTGACCCGAAACGGCCGGCCGGCTGCCGTGCTGATCAGCCCGGACGACCTTGAGAGCCTCGAAGAGACGCTGG
CGATCCTCTCCGACAGAGCGATGATGGAGAAGGTCCGCGAAGGCGATGCCGCCATCGCCGCCGGCGACTCGATCTCGCTC
GAAGAACTGCGGGCACAGCTCGGCCAGTCGCCGGCTGCGTGA

Structures

Toxin

• AlphaFold DB: D3FAL1