Detailed information of TA system TA245281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3802331..3804020
• Replicon: chromosome
• Accession: NZ_CP097360
• Organism: Escherichia coli strain AGR4587

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: M7749_RS18585
• Protein ID: WP_000365807.1
• Coordinates: 3802331..3803251 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: M7749_RS18590
• Protein ID: WP_001295795.1
• Coordinates: 3803238..3804020 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M7749_RS18545 (3797804)	3797804..3798514	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
M7749_RS18550 (3798821)	3798821..3799150	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
M7749_RS18555 (3799162)	3799162..3799328	-	167	Protein_3641	tail fiber assembly protein	-
M7749_RS18560 (3799399)	3799399..3800013	-	615	WP_001019923.1	YagU family protein	-
M7749_RS18565 (3800228)	3800228..3800413	-	186	WP_000146240.1	hypothetical protein	-
M7749_RS18570 (3800462)	3800462..3800620	+	159	Protein_3644	integrase	-
M7749_RS18575 (3800847)	3800847..3801182	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
M7749_RS18580 (3801390)	3801390..3802166	+	777	WP_000171155.1	site-specific integrase	-
M7749_RS18585 (3802331)	3802331..3803251	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M7749_RS18590 (3803238)	3803238..3804020	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
M7749_RS18595 (3804304)	3804304..3807402	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3762118..3811083	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T245281 WP_000365807.1 NZ_CP097360:c3803251-3802331 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT245281 WP_001295795.1 NZ_CP097360:c3804020-3803238 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0