Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2532535..2534123 Replicon chromosome
Accession NZ_CP097360
Organism Escherichia coli strain AGR4587

Toxin (Protein)


Gene name hipA Uniprot ID A0A061YM43
Locus tag M7749_RS12230 Protein ID WP_001125411.1
Coordinates 2532801..2534123 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A061YNW4
Locus tag M7749_RS12225 Protein ID WP_001296076.1
Coordinates 2532535..2532801 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7749_RS12210 (2528903) 2528903..2530354 + 1452 WP_000854638.1 tagaturonate reductase -
M7749_RS12215 (2530551) 2530551..2531465 + 915 WP_001296077.1 bestrophin family protein -
M7749_RS12220 (2531469) 2531469..2532227 - 759 WP_001286537.1 trans-aconitate 2-methyltransferase -
M7749_RS12225 (2532535) 2532535..2532801 + 267 WP_001296076.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M7749_RS12230 (2532801) 2532801..2534123 + 1323 WP_001125411.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
M7749_RS12235 (2534562) 2534562..2535080 + 519 WP_064735564.1 type 1 fimbrial major subunit FimA -
M7749_RS12240 (2535442) 2535442..2536152 + 711 WP_001195177.1 fimbria/pilus periplasmic chaperone -
M7749_RS12245 (2536194) 2536194..2538845 + 2652 WP_001545975.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49329.96 Da        Isoelectric Point: 7.7906

>T245277 WP_001125411.1 NZ_CP097360:2532801-2534123 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.34 Da        Isoelectric Point: 4.9632

>AT245277 WP_001296076.1 NZ_CP097360:2532535-2532801 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061YM43

Antitoxin

Source ID Structure
AlphaFold DB A0A061YNW4

References