Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 584331..585907 Replicon plasmid pVP-16-VB00198-1
Accession NZ_CP097357
Organism Vibrio parahaemolyticus strain 16-VB00198

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M5598_RS27250 Protein ID WP_264400186.1
Coordinates 584582..585907 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5598_RS27245 Protein ID WP_264400185.1
Coordinates 584331..584588 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5598_RS27220 (M5598_27165) 580310..581317 + 1008 WP_258667745.1 hypothetical protein -
M5598_RS27225 (M5598_27170) 581373..581777 + 405 WP_264400181.1 hypothetical protein -
M5598_RS27230 (M5598_27175) 581801..582253 - 453 WP_264400182.1 hypothetical protein -
M5598_RS27235 (M5598_27180) 582243..583115 - 873 WP_264400183.1 ATPase, T2SS/T4P/T4SS family -
M5598_RS27240 (M5598_27185) 583250..584095 + 846 WP_264400184.1 hypothetical protein -
M5598_RS27245 (M5598_27190) 584331..584588 + 258 WP_264400185.1 helix-turn-helix domain-containing protein Antitoxin
M5598_RS27250 (M5598_27195) 584582..585907 + 1326 WP_264400186.1 type II toxin-antitoxin system HipA family toxin Toxin
M5598_RS27255 (M5598_27200) 585943..586629 - 687 WP_264400187.1 hypothetical protein -
M5598_RS27260 (M5598_27205) 586743..587186 - 444 WP_264400188.1 EF-hand domain-containing protein -
M5598_RS27265 (M5598_27210) 587361..587624 - 264 WP_045592346.1 hypothetical protein -
M5598_RS27270 (M5598_27215) 587658..588062 - 405 WP_053317874.1 hypothetical protein -
M5598_RS27275 (M5598_27220) 588161..588823 - 663 WP_053314412.1 DUF262 domain-containing protein -
M5598_RS27280 (M5598_27225) 588878..589162 - 285 WP_053314411.1 hypothetical protein -
M5598_RS27285 (M5598_27230) 589262..589858 - 597 WP_053314410.1 hypothetical protein -
M5598_RS27290 (M5598_27235) 590058..590282 + 225 WP_021485441.1 hypothetical protein -
M5598_RS27295 (M5598_27240) 590291..590599 + 309 WP_258667753.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..882852 882852


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49429.69 Da        Isoelectric Point: 6.7014

>T245262 WP_264400186.1 NZ_CP097357:584582-585907 [Vibrio parahaemolyticus]
MVKQLRVLMNGESVGVFTKEPSGAHSFQYGEDWLNSSKSRPISLSIPLRREPYRGDIVINFFDNLLPDNPQVRDRIVARY
GAKTKQPFDLLEKIGRDSVGAITLIPEGEPIPEFKGIRATELSLIKLEQVLNSYADNIPLGMVDGNDDFRISIAGAQEKT
ALLKLDGRWYIPQGATPTTHIIKLPIGEIRTQDSVLDLTTSVDNELVCMRLSEAFGLPTASCDVIRAGGVRALAVERFDR
RFSQLKDWIVRLPQEDFCQVSGMPSASKYESDGGIGIEGIMDHLLGSEVPQEDRRTFMRSQVLFYLLAAIDGHSKNFSLF
IEPHGKYRLTPLYDIMSAYPLMGGRGLHERKIKLAMGLKASSGYKRKWHQIQPRHFIGTARLVKYSSDSMRDILDEFITD
CGQVIDLVGNDLPDDINENVRDKIFEGLTKSVKKLSLGLNE

Download         Length: 1326 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9663.00 Da        Isoelectric Point: 7.2045

>AT245262 WP_264400185.1 NZ_CP097357:584331-584588 [Vibrio parahaemolyticus]
MLITSSRQLAIHLRDERKSRKLSQAKVADPVGIKQDTVSKFEVNPETTSIQTLFRILSSLNLEMHIVPKGQSIEPKTDNE
SDETW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References