Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2366662..2367640 Replicon chromosome
Accession NZ_CP097351
Organism Bacillus cereus strain DQ01

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag M6D84_RS12160 Protein ID WP_000624974.1
Coordinates 2366662..2367399 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag M6D84_RS12165 Protein ID WP_000237818.1
Coordinates 2367512..2367640 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6D84_RS12140 (M6D84_12140) 2362304..2363086 + 783 WP_016512842.1 class I SAM-dependent methyltransferase -
M6D84_RS12145 (M6D84_12145) 2363244..2364920 - 1677 WP_048558851.1 alpha-keto acid decarboxylase family protein -
M6D84_RS12150 (M6D84_12150) 2365037..2365519 + 483 WP_000191887.1 MarR family winged helix-turn-helix transcriptional regulator -
M6D84_RS12155 (M6D84_12155) 2365686..2366423 + 738 WP_048558852.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
M6D84_RS12160 (M6D84_12160) 2366662..2367399 + 738 WP_000624974.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M6D84_RS12165 (M6D84_12165) 2367512..2367640 + 129 WP_000237818.1 hypothetical protein Antitoxin
M6D84_RS12170 (M6D84_12170) 2367713..2367889 + 177 WP_000852629.1 stage II sporulation protein SB -
M6D84_RS12175 (M6D84_12175) 2367909..2368298 - 390 WP_048558853.1 YxeA family protein -
M6D84_RS12180 (M6D84_12180) 2368510..2369979 + 1470 WP_000287547.1 beta-Ala-His dipeptidase -
M6D84_RS12185 (M6D84_12185) 2370225..2371034 + 810 WP_000664543.1 papain-like cysteine protease family protein -
M6D84_RS12190 (M6D84_12190) 2371060..2371662 + 603 WP_000517268.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28375.07 Da        Isoelectric Point: 8.3170

>T245259 WP_000624974.1 NZ_CP097351:2366662-2367399 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTHWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFTDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPSVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIIIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT245259 WP_000237818.1 NZ_CP097351:2367512-2367640 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References