Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 3897096..3897732 Replicon chromosome
Accession NZ_CP097349
Organism Cytobacillus pseudoceanisediminis strain BNO1

Toxin (Protein)


Gene name mazF Uniprot ID W7KPR3
Locus tag M5V91_RS21035 Protein ID WP_009336311.1
Coordinates 3897096..3897446 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A160MHA2
Locus tag M5V91_RS21040 Protein ID WP_026041666.1
Coordinates 3897451..3897732 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5V91_RS21000 (M5V91_20785) 3892460..3893254 - 795 WP_251175626.1 RNA polymerase sigma factor SigB -
M5V91_RS21005 (M5V91_20790) 3893232..3893704 - 473 Protein_4124 anti-sigma B factor RsbW -
M5V91_RS21010 (M5V91_20795) 3893701..3894033 - 333 WP_009336305.1 anti-sigma factor antagonist -
M5V91_RS21015 (M5V91_20800) 3894094..3895104 - 1011 WP_019381250.1 PP2C family protein-serine/threonine phosphatase -
M5V91_RS21020 (M5V91_20805) 3895116..3895517 - 402 WP_009336308.1 anti-sigma regulatory factor -
M5V91_RS21025 (M5V91_20810) 3895522..3895884 - 363 WP_009336309.1 STAS domain-containing protein -
M5V91_RS21030 (M5V91_20815) 3895881..3896714 - 834 WP_009336310.1 RsbT co-antagonist protein RsbRA -
M5V91_RS21035 (M5V91_20820) 3897096..3897446 - 351 WP_009336311.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
M5V91_RS21040 (M5V91_20825) 3897451..3897732 - 282 WP_026041666.1 CopG family ribbon-helix-helix protein Antitoxin
M5V91_RS21045 (M5V91_20830) 3898108..3899379 - 1272 WP_284521489.1 alanine racemase -
M5V91_RS21050 (M5V91_20835) 3899434..3900447 - 1014 WP_019381248.1 outer membrane lipoprotein carrier protein LolA -
M5V91_RS21055 (M5V91_20840) 3900591..3900944 - 354 WP_009336315.1 holo-ACP synthase -
M5V91_RS21060 (M5V91_20845) 3901109..3901834 + 726 WP_009336316.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T245257 WP_009336311.1 NZ_CP097349:c3897446-3897096 [Cytobacillus pseudoceanisediminis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10817.30 Da        Isoelectric Point: 7.2025

>AT245257 WP_026041666.1 NZ_CP097349:c3897732-3897451 [Cytobacillus pseudoceanisediminis]
VSDSSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A169FD46

Antitoxin

Source ID Structure
AlphaFold DB A0A160MHA2

References