Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3870010..3870667 Replicon chromosome
Accession NZ_CP097342
Organism Enterobacter hormaechei subsp. xiangfangensis strain va18651

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T9SH06
Locus tag M5K26_RS18545 Protein ID WP_023295382.1
Coordinates 3870010..3870420 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag M5K26_RS18550 Protein ID WP_003863437.1
Coordinates 3870401..3870667 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5K26_RS18525 (M5K26_18500) 3866009..3867742 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
M5K26_RS18530 (M5K26_18505) 3867748..3868461 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5K26_RS18535 (M5K26_18510) 3868490..3869386 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
M5K26_RS18540 (M5K26_18515) 3869487..3870008 + 522 WP_015571793.1 flavodoxin FldB -
M5K26_RS18545 (M5K26_18520) 3870010..3870420 - 411 WP_023295382.1 protein YgfX Toxin
M5K26_RS18550 (M5K26_18525) 3870401..3870667 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
M5K26_RS18555 (M5K26_18530) 3870962..3871942 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
M5K26_RS18560 (M5K26_18535) 3872054..3872713 - 660 WP_003863433.1 hemolysin III family protein -
M5K26_RS18565 (M5K26_18540) 3872980..3873711 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
M5K26_RS18570 (M5K26_18545) 3873828..3875261 + 1434 WP_045910760.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16291.18 Da        Isoelectric Point: 11.4775

>T245249 WP_023295382.1 NZ_CP097342:c3870420-3870010 [Enterobacter hormaechei subsp. xiangfangensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT245249 WP_003863437.1 NZ_CP097342:c3870667-3870401 [Enterobacter hormaechei subsp. xiangfangensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9SH06

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References