Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3144055..3145838 Replicon chromosome
Accession NZ_CP097342
Organism Enterobacter hormaechei subsp. xiangfangensis strain va18651

Toxin (Protein)


Gene name hipA Uniprot ID A0A2G5A822
Locus tag M5K26_RS15120 Protein ID WP_045333653.1
Coordinates 3144055..3145404 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2G5A843
Locus tag M5K26_RS15125 Protein ID WP_045333654.1
Coordinates 3145401..3145838 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5K26_RS15095 (M5K26_15075) 3139878..3140813 - 936 WP_015572323.1 tRNA dihydrouridine(16) synthase DusC -
M5K26_RS15100 (M5K26_15080) 3140982..3141377 + 396 WP_003859308.1 CidA/LrgA family protein -
M5K26_RS15105 (M5K26_15085) 3141374..3142069 + 696 WP_015572322.1 CidB/LrgB family autolysis modulator -
M5K26_RS15110 (M5K26_15090) 3142198..3143082 + 885 WP_017383380.1 cytidine deaminase -
M5K26_RS15115 (M5K26_15095) 3143210..3143920 + 711 WP_017383381.1 outer membrane permeability protein SanA -
M5K26_RS15120 (M5K26_15100) 3144055..3145404 + 1350 WP_045333653.1 HipA domain-containing protein Toxin
M5K26_RS15125 (M5K26_15105) 3145401..3145838 + 438 WP_045333654.1 helix-turn-helix transcriptional regulator Antitoxin
M5K26_RS15130 (M5K26_15110) 3145877..3146887 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
M5K26_RS15135 (M5K26_15115) 3146903..3148423 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
M5K26_RS15140 (M5K26_15120) 3148503..3149501 - 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
M5K26_RS15145 (M5K26_15125) 3149797..3150819 - 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51197.84 Da        Isoelectric Point: 4.6562

>T245247 WP_045333653.1 NZ_CP097342:3144055-3145404 [Enterobacter hormaechei subsp. xiangfangensis]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRTLINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPTT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16171.61 Da        Isoelectric Point: 10.5154

>AT245247 WP_045333654.1 NZ_CP097342:3145401-3145838 [Enterobacter hormaechei subsp. xiangfangensis]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G5A822

Antitoxin

Source ID Structure
AlphaFold DB A0A2G5A843

References