Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2406097..2406836 Replicon chromosome
Accession NZ_CP097342
Organism Enterobacter hormaechei subsp. xiangfangensis strain va18651

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag M5K26_RS11685 Protein ID WP_003857133.1
Coordinates 2406097..2406582 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag M5K26_RS11690 Protein ID WP_003857131.1
Coordinates 2406570..2406836 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5K26_RS11660 (M5K26_11650) 2401604..2402029 - 426 WP_000065802.1 glutaredoxin-dependent arsenate reductase -
M5K26_RS11665 (M5K26_11655) 2402042..2403331 - 1290 WP_000922628.1 arsenic transporter -
M5K26_RS11670 (M5K26_11660) 2403377..2403697 - 321 WP_000941305.1 transcriptional regulator -
M5K26_RS11675 (M5K26_11665) 2403784..2404488 + 705 WP_000130816.1 arsenical resistance protein ArsH -
M5K26_RS11680 (M5K26_11670) 2404521..2405924 - 1404 WP_000125668.1 ISNCY family transposase -
M5K26_RS11685 (M5K26_11675) 2406097..2406582 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
M5K26_RS11690 (M5K26_11680) 2406570..2406836 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
M5K26_RS11695 (M5K26_11685) 2406900..2407829 - 930 WP_045911831.1 LysR family transcriptional regulator -
M5K26_RS11700 (M5K26_11690) 2407959..2409341 + 1383 WP_045911739.1 MFS transporter -
M5K26_RS11705 (M5K26_11695) 2409363..2410358 - 996 WP_015570513.1 DUF2891 domain-containing protein -
M5K26_RS11710 (M5K26_11700) 2410368..2411354 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2404521..2405924 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T245241 WP_003857133.1 NZ_CP097342:c2406582-2406097 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT245241 WP_003857131.1 NZ_CP097342:c2406836-2406570 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References