245234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 907964..908561 Replicon chromosome
Accession NZ_CP097340
Organism Mannheimia haemolytica strain B-31

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M3703_RS04785 Protein ID WP_044427636.1
Coordinates 908286..908561 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A547EKP0
Locus tag M3703_RS04780 Protein ID WP_006249777.1
Coordinates 907964..908293 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3703_RS04755 (M3703_04755) 903413..904102 + 690 WP_006253589.1 GTP cyclohydrolase I FolE -
M3703_RS04760 (M3703_04760) 904167..904952 + 786 WP_006249781.1 tRNA pseudouridine(38-40) synthase TruA -
M3703_RS04765 (M3703_04765) 905005..907197 - 2193 WP_249762640.1 copper-translocating P-type ATPase -
M3703_RS04770 (M3703_04770) 907250..907450 - 201 WP_249762742.1 cation transporter -
M3703_RS04775 (M3703_04775) 907539..907925 + 387 WP_006249778.1 Cu(I)-responsive transcriptional regulator -
M3703_RS04780 (M3703_04780) 907964..908293 - 330 WP_006249777.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M3703_RS04785 (M3703_04785) 908286..908561 - 276 WP_044427636.1 type II toxin-antitoxin system HicA family toxin Toxin
M3703_RS04790 (M3703_04790) 908769..910676 + 1908 WP_044427633.1 DNA topoisomerase IV subunit B -
M3703_RS04795 (M3703_04795) 910750..911355 - 606 WP_006249773.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
M3703_RS04800 (M3703_04800) 911425..911781 + 357 WP_006252956.1 dihydroneopterin aldolase -
M3703_RS04805 (M3703_04805) 911778..912680 + 903 WP_006249771.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(28-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10384.08 Da        Isoelectric Point: 10.2600

>T245234 WP_044427636.1 NZ_CP097340:c908561-908286 [Mannheimia haemolytica]
MVVKILKRKSQKTLQQIYTQPISANIKWTNIEALFLELGAEIEEREGSRIAVVLFQQVRVFHRPHPNPDTDKGAVASIKK
WLSENGVIPYA

Download         Length: 276 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12312.06 Da        Isoelectric Point: 4.7022

>AT245234 WP_006249777.1 NZ_CP097340:c908293-907964 [Mannheimia haemolytica]
MRNIMDINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVIQLKKEGELSLNIFLELCREKGIEPFKQYSGKFNVRLSP
ELHKAAVIAATAENLSLNEWINQTLEKSV

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A547EKP0

References