245229

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 2316148..2316863 Replicon chromosome
Accession NZ_CP097339
Organism Mannheimia haemolytica strain H-5106

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M3710_RS11455 Protein ID WP_006250491.1
Coordinates 2316148..2316576 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A248ZW87
Locus tag M3710_RS11460 Protein ID WP_006248272.1
Coordinates 2316576..2316863 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3710_RS11440 (M3710_11440) 2311402..2313054 + 1653 WP_006248275.1 phospho-sugar mutase -
M3710_RS11445 (M3710_11445) 2313107..2314041 + 935 Protein_2234 nucleoside hydrolase -
M3710_RS11450 (M3710_11450) 2314063..2316144 - 2082 WP_006248274.1 ATP-dependent DNA helicase RecG -
M3710_RS11455 (M3710_11455) 2316148..2316576 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
M3710_RS11460 (M3710_11460) 2316576..2316863 - 288 WP_006248272.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M3710_RS11465 (M3710_11465) 2317027..2318910 + 1884 WP_249762186.1 molecular chaperone HtpG -
M3710_RS11470 (M3710_11470) 2318999..2319145 + 147 WP_230269068.1 hypothetical protein -
M3710_RS11475 (M3710_11475) 2319309..2321024 + 1716 WP_006248268.1 proline--tRNA ligase -
M3710_RS11480 (M3710_11480) 2321136..2321182 + 47 Protein_2241 carbamate kinase -
M3710_RS11485 (M3710_11485) 2321175..2321220 + 46 Protein_2242 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T245229 WP_006250491.1 NZ_CP097339:c2316576-2316148 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11085.39 Da        Isoelectric Point: 4.3648

>AT245229 WP_006248272.1 NZ_CP097339:c2316863-2316576 [Mannheimia haemolytica]
MAITITSREFNQNASKVLKMAEKEPVFITKWGKIVNVVSSYMDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVE
IRKSNKPRPVDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZW87

References