Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1760407..1761057 Replicon chromosome
Accession NZ_CP097339
Organism Mannheimia haemolytica strain H-5106

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag M3710_RS08715 Protein ID WP_006249411.1
Coordinates 1760407..1760796 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag M3710_RS08720 Protein ID WP_006249412.1
Coordinates 1760797..1761057 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3710_RS08670 (M3710_08670) 1755886..1756695 - 810 WP_006250123.1 metal ABC transporter permease -
M3710_RS08675 (M3710_08675) 1756688..1757548 - 861 WP_006250124.1 metal ABC transporter permease -
M3710_RS08680 (M3710_08680) 1757622..1758407 - 786 WP_006251768.1 hypothetical protein -
M3710_RS08710 (M3710_08710) 1759149..1760387 - 1239 WP_006253630.1 peptidase T -
M3710_RS08715 (M3710_08715) 1760407..1760796 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
M3710_RS08720 (M3710_08720) 1760797..1761057 - 261 WP_006249412.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M3710_RS08725 (M3710_08725) 1761173..1761385 - 213 WP_006251765.1 BrnA antitoxin family protein -
M3710_RS08730 (M3710_08730) 1761386..1761673 - 288 WP_006251764.1 BrnT family toxin -
M3710_RS08735 (M3710_08735) 1761836..1765369 - 3534 WP_006253629.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T245228 WP_006249411.1 NZ_CP097339:c1760796-1760407 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT245228 WP_006249412.1 NZ_CP097339:c1761057-1760797 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A547EDM1

References