245223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 69325..69847 Replicon chromosome
Accession NZ_CP097339
Organism Mannheimia haemolytica strain H-5106

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZX63
Locus tag M3710_RS00365 Protein ID WP_006250322.1
Coordinates 69578..69847 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A248ZY54
Locus tag M3710_RS00360 Protein ID WP_006250323.1
Coordinates 69325..69591 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3710_RS00345 (M3710_00345) 66186..67571 - 1386 WP_209025940.1 GTPase HflX -
M3710_RS00350 (M3710_00350) 67591..67863 - 273 WP_126301178.1 RNA chaperone Hfq -
M3710_RS00355 (M3710_00355) 67932..68885 - 954 WP_209025939.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
M3710_RS00360 (M3710_00360) 69325..69591 + 267 WP_006250323.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3710_RS00365 (M3710_00365) 69578..69847 + 270 WP_006250322.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
M3710_RS00370 (M3710_00370) 69866..71749 - 1884 WP_006251983.1 DNA mismatch repair endonuclease MutL -
M3710_RS00375 (M3710_00375) 72033..73271 + 1239 WP_006250320.1 glutamate-5-semialdehyde dehydrogenase -
M3710_RS00380 (M3710_00380) 73273..74118 + 846 WP_006250319.1 virulence factor BrkB family protein -
M3710_RS00385 (M3710_00385) 74093..74527 + 435 WP_006250318.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10447.99 Da        Isoelectric Point: 6.4732

>T245223 WP_006250322.1 NZ_CP097339:69578-69847 [Mannheimia haemolytica]
MREIEYSNAFKRDYKKCAVESLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKVEDDKLELLR
IGSHSHLFG

Download         Length: 270 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9738.10 Da        Isoelectric Point: 4.7954

>AT245223 WP_006250323.1 NZ_CP097339:69325-69591 [Mannheimia haemolytica]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETAEVLRAVKNGEEKLHSANSIADL
MEQLNARD

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZX63

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZY54

References