Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2182636..2183286 Replicon chromosome
Accession NZ_CP097338
Organism Mannheimia haemolytica strain P1148

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag M3708_RS11205 Protein ID WP_006249411.1
Coordinates 2182636..2183025 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag M3708_RS11210 Protein ID WP_006249412.1
Coordinates 2183026..2183286 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3708_RS11160 (M3708_11160) 2178114..2178923 - 810 WP_006250123.1 metal ABC transporter permease -
M3708_RS11165 (M3708_11165) 2178916..2179776 - 861 WP_006250124.1 metal ABC transporter permease -
M3708_RS11170 (M3708_11170) 2179850..2180635 - 786 WP_006251768.1 hypothetical protein -
M3708_RS11200 (M3708_11200) 2181378..2182616 - 1239 WP_006253630.1 peptidase T -
M3708_RS11205 (M3708_11205) 2182636..2183025 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
M3708_RS11210 (M3708_11210) 2183026..2183286 - 261 WP_006249412.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M3708_RS11215 (M3708_11215) 2183402..2183614 - 213 WP_006251765.1 BrnA antitoxin family protein -
M3708_RS11220 (M3708_11220) 2183615..2183902 - 288 WP_006251764.1 BrnT family toxin -
M3708_RS11225 (M3708_11225) 2184065..2187598 - 3534 WP_006253629.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T245221 WP_006249411.1 NZ_CP097338:c2183025-2182636 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT245221 WP_006249412.1 NZ_CP097338:c2183286-2183026 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A547EDM1

References