Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1891143..1891665 Replicon chromosome
Accession NZ_CP097338
Organism Mannheimia haemolytica strain P1148

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag M3708_RS09720 Protein ID WP_006249269.1
Coordinates 1891369..1891665 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag M3708_RS09715 Protein ID WP_006249270.1
Coordinates 1891143..1891385 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3708_RS09690 (M3708_09690) 1886981..1888070 - 1090 Protein_1885 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
M3708_RS09695 (M3708_09695) 1888244..1888885 - 642 WP_006249274.1 orotate phosphoribosyltransferase -
M3708_RS09700 (M3708_09700) 1889008..1889850 - 843 WP_006249273.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
M3708_RS09705 (M3708_09705) 1889910..1890485 + 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
M3708_RS09710 (M3708_09710) 1890463..1891131 - 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
M3708_RS09715 (M3708_09715) 1891143..1891385 - 243 WP_006249270.1 CopG family antitoxin Antitoxin
M3708_RS09720 (M3708_09720) 1891369..1891665 - 297 WP_006249269.1 BrnT family toxin Toxin
M3708_RS09725 (M3708_09725) 1891792..1894704 - 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
M3708_RS09730 (M3708_09730) 1894865..1895164 - 300 WP_006249265.1 hypothetical protein -
M3708_RS09735 (M3708_09735) 1895285..1896610 - 1326 WP_006249264.1 anti-phage deoxyguanosine triphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T245220 WP_006249269.1 NZ_CP097338:c1891665-1891369 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT245220 WP_006249270.1 NZ_CP097338:c1891385-1891143 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References