Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 53..645 | Replicon | plasmid pCROD2 |
Accession | NC_013718 | ||
Organism | Citrobacter rodentium ICC168 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | V0AGQ2 |
Locus tag | ROD_RS25275 | Protein ID | WP_000520549.1 |
Coordinates | 397..645 (-) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | V0AWG0 |
Locus tag | ROD_RS25270 | Protein ID | WP_000681613.1 |
Coordinates | 53..400 (-) | Length | 116 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ROD_RS25270 | 53..400 | - | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
ROD_RS25275 | 397..645 | - | 249 | WP_000520549.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
ROD_RS25280 | 951..1301 | - | 351 | WP_000854261.1 | hypothetical protein | - |
ROD_RS25285 | 1393..1692 | - | 300 | WP_000650311.1 | hypothetical protein | - |
ROD_RS27235 | 2146..2373 | - | 228 | WP_000801440.1 | hypothetical protein | - |
ROD_RS25290 | 2360..2611 | - | 252 | WP_001230707.1 | hypothetical protein | - |
ROD_RS25295 | 2608..3150 | - | 543 | WP_012908950.1 | hypothetical protein | - |
ROD_RS25300 | 3255..3770 | - | 516 | WP_001025397.1 | J domain-containing protein | - |
ROD_RS25305 | 4410..4760 | - | 351 | WP_000312755.1 | hypothetical protein | - |
ROD_RS25310 | 4784..5065 | - | 282 | WP_000220561.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
ROD_RS25315 | 5055..5306 | - | 252 | WP_000121743.1 | plasmid stabilization protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..39265 | 39265 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9422.08 Da Isoelectric Point: 10.4800
>T24522 WP_000520549.1 NC_013718:c645-397 [Citrobacter rodentium ICC168]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL
Download Length: 249 bp
>T24522 NC_013718:c645-397 [Citrobacter rodentium ICC168]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13113.84 Da Isoelectric Point: 4.6723
>AT24522 WP_000681613.1 NC_013718:c400-53 [Citrobacter rodentium ICC168]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA
Download Length: 348 bp
>AT24522 NC_013718:c400-53 [Citrobacter rodentium ICC168]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGACTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGACTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CIX3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CLC1 |