Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 905015..905611 Replicon chromosome
Accession NZ_CP097338
Organism Mannheimia haemolytica strain P1148

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M3708_RS04620 Protein ID WP_006249776.1
Coordinates 905387..905611 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A547EKP0
Locus tag M3708_RS04615 Protein ID WP_006249777.1
Coordinates 905015..905344 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3708_RS04590 (M3708_04590) 900464..901153 + 690 WP_006253589.1 GTP cyclohydrolase I FolE -
M3708_RS04595 (M3708_04595) 901218..902003 + 786 WP_006249781.1 tRNA pseudouridine(38-40) synthase TruA -
M3708_RS04600 (M3708_04600) 902056..904248 - 2193 WP_006249780.1 copper-translocating P-type ATPase -
M3708_RS04605 (M3708_04605) 904301..904501 - 201 WP_006249779.1 heavy metal-associated domain-containing protein -
M3708_RS04610 (M3708_04610) 904590..904976 + 387 WP_006249778.1 Cu(I)-responsive transcriptional regulator -
M3708_RS04615 (M3708_04615) 905015..905344 - 330 WP_006249777.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M3708_RS04620 (M3708_04620) 905387..905611 - 225 WP_006249776.1 type II toxin-antitoxin system HicA family toxin Toxin
M3708_RS04625 (M3708_04625) 905819..907726 + 1908 WP_006249774.1 DNA topoisomerase IV subunit B -
M3708_RS04630 (M3708_04630) 907800..908405 - 606 WP_006249773.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
M3708_RS04635 (M3708_04635) 908475..908831 + 357 WP_006249772.1 dihydroneopterin aldolase -
M3708_RS04640 (M3708_04640) 908828..909730 + 903 WP_006249771.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(28-73)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 10.5597

>T245216 WP_006249776.1 NZ_CP097338:c905611-905387 [Mannheimia haemolytica]
MVVKILKRKSQKTLQQIYTQPISANIKWTNIEALFLELGAEIEEREGSRIAVVLFQQVRVFHRPHPNPDTDKGR

Download         Length: 225 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12312.06 Da        Isoelectric Point: 4.7022

>AT245216 WP_006249777.1 NZ_CP097338:c905344-905015 [Mannheimia haemolytica]
MRNIMDINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVIQLKKEGELSLNIFLELCREKGIEPFKQYSGKFNVRLSP
ELHKAAVIAATAENLSLNEWINQTLEKSV

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A547EKP0

References